Anti-CCR3 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your expert partner for all allergy and immunology applications, offering highly specific anti-CCR3 recombinant antibodies. CCR3 is the primary chemokine receptor involved in the recruitment of eosinophils during allergic inflammation and asthma. Our premium antibodies allow for the investigation of allergic disease mechanisms as well as the development of targeted treatments for eosinophilic disorders.

CCR3: The Eosinophil Chemotactic Receptor

C-C Motif Chemokine Receptor 3 (CCR3) is a G-protein coupled receptor (GPCR) that is most highly expressed on eosinophils, a central player in allergic inflammation. It is also expressed on basophils as well as certain T-cell subsets. CCR3 has high affinity for the chemokines CCL11 (eotaxin-1), CCL24 (eotaxin-2) and CCL26 (eotaxin-3). The binding of these chemokines provides the primary signal to recruit eosinophils from the circulation into the tissue of interest, such as the airways in asthma or the esophagus in eosinophilic esophagitis. Eosinophils and the toxic granule proteins they release are a major cause of pathology in these diseases, which is why CCR3 is a major therapeutic target.

Alternative Names

CCR3; Eosinophil CC Chemokine Receptor 3; CC Chemokine Receptor 3; Eosinophil Eotaxin Receptor; CC-CKR-3; CD193 Antigen; Chemokine (C-C Motif) Receptor 3; CD193; CKR3; CCR-3; B-Chemokine Receptor; C-C Chemokine Receptor Type 3; C-C CKR-3; CMKBR3

Background

CCR3 (C-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CCR3 include Folliculotropic Mycosis Fungoides and Aids Dementia Complex. Among its related pathways are Akt Signaling and IL1 and megakaryocytes in obesity. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR1.

Anti-CCR3 rAb Products

Our anti-CCR3 recombinant antibodies are designed for superior specificity and performance. They are carefully validated to reliably detect CCR3 receptor expression on the cell surface of eosinophils. Optimized for use in multi-color flow cytometry applications for eosinophil identification and quantification, as well as for functional blocking of chemotaxis, our rAbs provide the performance you need for detailed allergy research.

Table 1. Featured anti-CCR3 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is committed to the field of allergy research, using cutting edge production platforms for our anti-CCR3 recombinant antibodies. Expressed in optimized systems, our antibodies are made to reliably recognize the native receptor. We are focused on guaranteeing that the products we provide are a highly specific and active tool for your research.

Featured Anti-CCR3 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CCR3 recombinant antibody production.

Fig.2 Gram-scale anti-CCR3 recombinant antibody production.

rAb Modalities

Creative Biolabs is focused on enabling scientific discovery by providing a range of flexible antibody solutions for our customers. Our anti-CCR3 recombinant antibodies are available in a variety of formats, including functional blocking clones, to meet the needs of different experimental applications and empower researchers around the globe to investigate this key receptor.

Fig.3 Full-length anti-CCR3 recombinant antibody production and modalities.

CCR3-Targeted Drug Information

Table 2. Public drug targeting CCR3.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs’ anti-CCR3 recombinant antibodies are the precise tools you need to dissect the mechanisms of allergic inflammation. We provide the validation and consistency you can trust to further your investigation of this key therapeutic target. Let our expertise be the foundation for your research. Contact our scientific team today.