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    CCR7

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
    Protein class

    Cancer-related genes, CD markers, G-protein coupled receptors

    Predicted location

    Membrane

    Single cell type specificity

    Group enriched (monocytes, Syncytiotrophoblasts, Langerhans cells)

    Immune cell specificity

    Immune cell enhanced (naive CD4 T-cell)

    Cell line specificity

    Cell line enriched (HDLM-2)

    Molecular function

    G-protein coupled receptor, Receptor, Transducer

    More Types Infomation
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