Anti-CDC42 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your source for top quality cell biology reagents, and our anti-CDC42 recombinant antibodies are no exception. As a critical upstream regulator of the actin cytoskeleton and cell polarity, Cell Division Control Protein 42 (CDC42) is a foundational GTPase that coordinates a diverse set of cellular functions. Our premium antibodies are a powerful tool for probing cell migration, division, morphogenesis, and more, as well as its dysregulation in cancer and developmental disease.

CDC42: A Master Regulator of Cell Polarity and the Cytoskeleton

CDC42 is a member of the Rho family of small GTPases, which function as molecular switches cycling between an inactive GDP-bound form and an active GTP-bound form. In the active state, it interacts with diverse effector proteins to regulate a host of fundamental cellular processes. It is most well-known for its role as a master regulator of cell polarity, defining the axis of migration and organizing the cytoskeleton. It does this primarily through the activation of effector kinases that regulate the actin-nucleating Arp2/3 complex, resulting in the generation of filopodia and lamellipodia, the protrusions responsible for cell movement. Its activity is required for everything from wound healing to neuronal development.

Alternative Names

TKS; G25K; CDC42Hs; G25K GTP-binding protein; GTP binding protein, 25kDa; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); growth-regulating protein; small GTP binding protein CDC42

Background

CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Takenouchi-Kosaki Syndrome and Temperature-Sensitive Lethal Mutation. Among its related pathways are Development EGFR signaling via small GTPases and RANK Signaling in Osteoclasts. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is RAC1.

Anti-CDC42 rAb Products

Our anti-CDC42 recombinant antibodies have been engineered for superior specificity and performance. Critically, we offer conformation-specific antibodies that only recognize the active, GTP-bound form of CDC42, enabling direct visualization and quantitation of its activation. We also offer high-quality total CDC42 antibodies for detection of total CDC42 levels, optimized for Western Blot and IHC.

Table 1. Featured anti-CDC42 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs’ number one priority is to support world-class research, and production of our anti-CDC42 recombinant antibodies is no exception. Our production is overseen by a robust quality control system, and each lot, particularly our active-form specific antibodies, is thoroughly validated for purity, specificity, and consistent performance in a panel of validated activation assays.

Customer Reviews

rAb Production

Creative Biolabs harnesses cutting-edge production platforms to enable novel therapies to move faster. Our anti-active CDC42 recombinant antibodies are carefully developed and screened to give you a unique and powerful tool to directly study the dynamics of GTPase signaling.

Featured Anti-CDC42 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CDC42 recombinant antibody production.

Fig.4 Gram-scale anti-CDC42 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing our researchers with innovative solutions for cell biology research. Our anti-CDC42 recombinant antibodies are available in a wide range of modalities to help researchers around the world study this important master regulator of the cell.

Fig.5 Full-length anti-CDC42 recombinant antibody production and modalities.

Target this key GTPase with Creative Biolabs’ top-quality anti-CDC42 recombinant antibodies. Our collection features unique active-form specific reagents that provide the precision necessary to study the dynamic regulation of the cytoskeleton. Put our expertise to work for you and your research by contacting our scientific team today.