Rabbit Anti-EGFRvIII Recombinant Antibody (VS-1225-XY78)
CAT#: VS-1225-XY78
It binds EGFRvIII specifically, avoiding cross-reactivity with wild-type EGFR. This antibody supports oncology research, suitable for ELISA, WB, and IHC to analyze EGFRvIII expression in tumor tissues.
Specifications
- Host Animal
- Rabbit
- Applications
- WB, IHC, FC, ELISA
- Specificity
- EGFRvIII
- Target
- EGFRvIII
- Species Reactivity
- Human
- Type
- Rabbit IgG
- Purity
- >95%, determined by SDS-PAGE
- Purification
- Protein A purified
- Format
- Liquid
- Buffer
- PBS with 50% glycerol, 1% BSA
- Preservative
- 0.09% sodium azide
- Storage
- Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
Target
- Introduction
- EGFRvIII is a constitutively active, ligand-independent mutant of epidermal growth factor receptor (EGFR), arising from the in-frame deletion of exons 2-7 in the EGFR gene. This deletion eliminates the extracellular ligand-binding domain, triggering spontaneous dimerization and persistent activation of oncogenic signaling pathways (e.g., RAS/RAF/MEK/ERK, PI3K/AKT/mTOR) that drive cell proliferation, survival and metastasis. Uniquely absent in normal tissues but abundant in multiple malignancies (e.g., glioblastoma, non-small cell lung cancer), EGFRvIII serves as a highly attractive target for cancer diagnosis and targeted therapy.
- Alternative Names
- Epidermal Growth Factor Receptor, Variant III
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "EGFRvIII"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-310 | Recombinant Anti-EGFRvIII Antibody | ELISA, WB, Dot, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-310-F(E) | Recombinant Anti-EGFRvIII Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-310-S(P) | Recombinant Anti-EGFRvIII Antibody scFv Fragment | Neut, WB, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-310 | Recombinant Human Anti-EGFRvIII Antibody | IF, ELISA, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-310-F(E) | Recombinant Human Anti-EGFRvIII Antibody Fab Fragment | RIA, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-310-S(P) | Recombinant Human Anti-EGFRvIII Antibody scFv Fragment | IF, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0111LY | Mouse Anti-EGFRvIII Recombinant Antibody (HPAB-0111LY) | FC, Cyt | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0483LY | Human Anti-EGFRvIII Recombinant Antibody (clone CBL009LY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0111LY-S(P) | Mouse Anti-EGFRvIII Recombinant Antibody scFv Fragment (HPAB-0111LY-S(P)) | FC, Cyt | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0111LY-F(E) | Mouse Anti-EGFRvIII Recombinant Antibody Fab Fragment (HPAB-0111LY-F(E)) | FC, Cyt | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0483LY-S(P) | Human Anti-EGFRvIII Recombinant Antibody (clone CBL009LY); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0483LY-F(E) | Human Anti-EGFRvIII Recombinant Antibody (clone CBL009LY); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-648-FY | Human Anti-EGFRvIII Recombinant Antibody (HPAB-648-FY) | FC, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-648-FY-S(P) | Human Anti-EGFRvIII Recombinant Antibody; scFv Fragment (HPAB-648-FY-S(P)) | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-648-FY-F(E) | Human Anti-EGFRvIII Recombinant Antibody; Fab Fragment (HPAB-648-FY-F(E)) | FC, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC111 | SmartAb™ Recombinant Anti-EGFRvIII pH-dependent Antibody (VS-0825-YC111) | ELISA, Inhib | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-XY77 | Rabbit Anti-EGFRvIII Recombinant Antibody (VS-1225-XY77) | IHC | Rabbit IgG |
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