Rabbit Anti-EGFRvIII Recombinant Antibody (VS-1225-XY77)
CAT#: VS-1225-XY77
This engineered immunoglobulin targets EGFRvIII, with a specific Fab and stable Fc. It has tailored affinity for research, applicable in ELISA, WB, and IHC for EGFRvIII detection in biological samples.
Specifications
- Host Animal
- Rabbit
- Applications
- IHC
- Specificity
- EGFRvIII
- Target
- EGFRvIII
- Species Reactivity
- Human
- Type
- Rabbit IgG
- Purity
- >95%, determined by SDS-PAGE
- Purification
- Protein A purified
- Format
- Liquid
- Buffer
- PBS, pH 7.4, with 0.05% BSA
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
Target
- Introduction
- EGFRvIII is a constitutively active, ligand-independent mutant of epidermal growth factor receptor (EGFR), arising from the in-frame deletion of exons 2-7 in the EGFR gene. This deletion eliminates the extracellular ligand-binding domain, triggering spontaneous dimerization and persistent activation of oncogenic signaling pathways (e.g., RAS/RAF/MEK/ERK, PI3K/AKT/mTOR) that drive cell proliferation, survival and metastasis. Uniquely absent in normal tissues but abundant in multiple malignancies (e.g., glioblastoma, non-small cell lung cancer), EGFRvIII serves as a highly attractive target for cancer diagnosis and targeted therapy.
- Alternative Names
- Epidermal Growth Factor Receptor, Variant III
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1225-XY77. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "EGFRvIII"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-310 | Recombinant Anti-EGFRvIII Antibody | ELISA, WB, Dot, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-310-F(E) | Recombinant Anti-EGFRvIII Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-310-S(P) | Recombinant Anti-EGFRvIII Antibody scFv Fragment | Neut, WB, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-310 | Recombinant Human Anti-EGFRvIII Antibody | IF, ELISA, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-310-F(E) | Recombinant Human Anti-EGFRvIII Antibody Fab Fragment | RIA, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-310-S(P) | Recombinant Human Anti-EGFRvIII Antibody scFv Fragment | IF, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0111LY | Mouse Anti-EGFRvIII Recombinant Antibody (HPAB-0111LY) | FC, Cyt | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0483LY | Human Anti-EGFRvIII Recombinant Antibody (clone CBL009LY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0111LY-S(P) | Mouse Anti-EGFRvIII Recombinant Antibody scFv Fragment (HPAB-0111LY-S(P)) | FC, Cyt | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0111LY-F(E) | Mouse Anti-EGFRvIII Recombinant Antibody Fab Fragment (HPAB-0111LY-F(E)) | FC, Cyt | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0483LY-S(P) | Human Anti-EGFRvIII Recombinant Antibody (clone CBL009LY); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0483LY-F(E) | Human Anti-EGFRvIII Recombinant Antibody (clone CBL009LY); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-648-FY | Human Anti-EGFRvIII Recombinant Antibody (HPAB-648-FY) | FC, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-648-FY-S(P) | Human Anti-EGFRvIII Recombinant Antibody; scFv Fragment (HPAB-648-FY-S(P)) | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-648-FY-F(E) | Human Anti-EGFRvIII Recombinant Antibody; Fab Fragment (HPAB-648-FY-F(E)) | FC, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC111 | SmartAb™ Recombinant Anti-EGFRvIII pH-dependent Antibody (VS-0825-YC111) | ELISA, Inhib | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-XY78 | Rabbit Anti-EGFRvIII Recombinant Antibody (VS-1225-XY78) | WB, IHC, FC, ELISA | Rabbit IgG |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
