GLP1R

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For Research Use Only. Not For Clinical Use.


Background

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:9568699). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (By similarity). Plays a role in regulating insulin secretion in response to GLP-1 (PubMed:9568699).
Protein class

FDA approved drug targets, G-protein coupled receptors, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Cardiomyocytes, Inhibitory neurons, Early spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (NTERA-2, SCLC-21H)

Interaction

May form homodimers and heterodimers with GIPR.

Molecular function

G-protein coupled receptor, Receptor, Transducer

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