Human Anti-GLP1R Recombinant Antibody (clone 5A10) (CAT#: NS-031CN)
Anti-GLP1R antibody can be used for the treatment of diabetes, obesity, neurodegenerative diseases, and complications related to cardiac ischemia and reperfusion injury.
Specific Inquiry
FC
Figure 1 FACS analysis which shows GLP1R specific antibodies derived from whole cell immunization display selective binding for transfected cells displaying the human GLP1R.
FuncS
Figure 2 Monoclonal antibodies 5A10 and 9A10 allosterically enhance intracellular cAMP response of human GLP1R while mAb 2A9 is allosterically inert.
FuncS
Figure 3 Monoclonal antibodies 5A10 and 9A10 maintain allosteric activity between 100 and 1000 picomolar of GLP-1 in an antibody dose-dependent manner.
FuncS
Figure 4 Allosteric antibodies increase the sensitivity of GLP1R while amplifying the magnitude of cAMP response to GLP-1 peptide.
Specifications
- Immunogen
- KLH-coupled peptide that mimic the extracellular loop of the human GLP-1 receptor
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human GLP1R
- Species Reactivity
- Human
- Clone
- 5A10
- Applications
- ELISA, FC
- Related Disease
- Diabetes
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry, Functional Assay.
Target
- Alternative Names
- GLP1R; glucagon-like peptide 1 receptor; GLP-1R; GLP-1-R; GLP-1 receptor
- Gene ID
- 2740
- UniProt ID
- P43220
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Neuroscience Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2540z | Mouse Anti-GLP1R Recombinant Antibody (MOB-2540z) | ELISA, WB, IP, IF, IHC, FC | Mouse IgG2b, κ |
| HPAB-0384-YC | Human Anti-GLP1R Recombinant Antibody (HPAB-0384-YC) | ELISA, FC, FuncS | Human IgG |
| HPAB-1530-FY | Human Anti-GLP1R Recombinant Antibody (HPAB-1530-FY) | ELISA, Inhib, IHC | Human IgG1, κ |
| HPAB-1531-FY | Mouse Anti-GLP1R Recombinant Antibody (HPAB-1531-FY) | ELISA, Inhib, IHC | Mouse IgG2a |
| VS4-WK197 | Human Anti-GLP1R Recombinant Antibody (clone 7H7) | ELISA | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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