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Anti-HER2 Recombinant Antibody Products
At Creative Biolabs, we use cutting-edge platforms to provide a comprehensive range of premium HER2-targeted recombinant antibodies to clients worldwide. Our mission is to advance research and discovery by providing unparalleled value and exceptional technical support, allowing our clients to achieve their scientific goals with greater efficiency and success.
HER2: A Crucial Target in Cancer Therapy
HER2 is a membrane-bound tyrosine kinase and oncogene that, when activated, delivers strong proliferative and anti-apoptotic signals to the cell. Overexpression and amplification of the HER2 protein have been associated with key pathways involved in the proliferation and survival of tumor cells, notably in breast, ovarian, and gastric cancers. Due to its significant role in cancer, HER2 serves as a vital marker for clinical treatment monitoring and prognosis. Furthermore, it is a crucial target in the development and selection of targeted therapies for cancer treatment.
Anti-HER2 Recombinant Antibody Products
We are dedicated to advancing your research and innovation forward with high-quality anti-HER2 recombinant antibodies at competitive prices and exemplary technical assistance. Explore our selection of anti-HER2 recombinant antibodies in the list below or click the link for more details and to choose the most suitable option for your research needs.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| TAB-0195CL | Anti-Human HER2 Recombinant Antibody (Anti-HER2-IgGl) | Human | Human antibody | FC, Cyt |
| TAB-0195CL-S(P) | Anti-Human HER2 Recombinant Antibody scFv Fragment (Anti-HER2-IgGl) | Human | Human antibody | FC, Cyt |
| TAB-0195CL-F(E) | Anti-Human HER2 Recombinant Antibody Fab Fragment (Anti-HER2-IgGl) | Human | Human antibody | FC, Cyt |
| VS3-FY665 | Recombinant Mouse Anti-ERBB2 Antibody (VS3-FY665) | Human, Mouse, Rat | Mouse IgG | WB, IHC |
Creative Quality Control
Our commitment lies in propelling breakthroughs in biopharmaceutical research through the provision of high-quality products and unparalleled customer support. Our strict quality management system ensures that our anti-HER2 recombinant antibodies not only comply with but exceed industry standards. Partner with us to enhance your research and innovation, benefiting from our commitment to quality and customer satisfaction.
Fig.1 SDS-PAGE analysis of Anti-HER2/Neu (KIFGSLAFL) TCR-Like Antibody (SF2), HLA-A2-Restricted.
(Cat# TCR-LA-LX0930, Creative Biolabs)
Customer Reviews
Excellent
Ri***doAnti-Human HER2 Recombinant Antibody (Anti-HER2-IgGl) (TAB-0195CL)
The product is used for detecting and quantifying HER2 in human extracellular vesicles BT-474 cell lysate. The high specificity and sensitivity of this antibody made me complete the assay in less than 3 hours with good results.
21/Oct/2023 6 Likes
Excellent
Be***ziAnti-Human HER2 Recombinant Antibody Fab Fragment (TAB-0195CL-F(E))
I acquired this product and employed it to block the HER2/neu signaling pathway in breast cell lines. I was impressed its specific is so excellent. In addition, during the use process, Creative Biolabs also provided comprehensive services to help me determine the optimal concentration and other details. Worthy of praise!
5/Jul/2024 3 Likes
Excellent
Elo**aRecombinant Mouse Anti-ERBB2 Antibody (VS3-FY665) (VS3-FY665)
I utilized this product to assess the expression level of ERBB2 in various breast cell lines by WB analysis. I observed significantly different positive rates among these cells and no background interference at the suggested concentrations.
26/Mar2024 3 Likes
Anti-HER2 Recombinant Antibody Production
Our advanced serum-free platform streamlines the production of high-quality anti-HER2 recombinant antibodies from gene synthesis through to milligram-to-gram scale output. With a wealth of expertise and experience, we've optimized expression vectors, cloning systems, and high-yielding mammalian cell lines for superior results.
Featured Anti-HER2 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-HER2 recombinant antibody production.
Fig.3 Gram-scale anti-HER2 recombinant antibody production.
Anti-HER2 Recombinant Antibody Modalities
Creative Biolabs offers customizable anti-HER2 recombinant antibodies in multiple formats, including full-length, Fab, scFv, etc., to support diverse research needs.
Fig.4 Full-Length Anti-HER2 Recombinant Antibody Production and Modalities.
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; TKR1; MLN 19; CD340; NGL; NEU; HER-2/neu; EC 2.7.10.1
Background
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
HER2-Targeted Drug Under Development
Table 1. HER2-targeted drug information (under development).
| Company | Highest Phase | Classification | Condition |
|
GC Biopharma Green Cross (GC Biopharma) MacroGenics (Originator) Zai Lab Zai Lab |
Launched-2021 |
Cancer Immunotherapy Chimeric Monoclonal Antibodies |
Cancer Cancer, breast Cancer, breast, metastatic Cancer, gastroesophageal junction Cancer, solid tumor Cancer, stomach |
|
Accord Healthcare Intas Pharmaceuticals Shanghai Henlius Biotech (Originator) |
Launched-2020 |
Cancer Immunotherapy Follow-on Products Humanized Monoclonal Antibodies |
Cancer, breast Cancer, breast (adenocarcinoma) Cancer, breast, metastatic Cancer, gastroesophageal junction Cancer, stomach, metastatic |
|
AffaMed Therapeutics Daewoong Merck & Co Merck & Co. (Merck & Co) Mundipharma Samsung Bioepis (Originator) |
Launched-2018 |
Biosimilars Cancer Immunotherapy Follow-on Products Humanized Monoclonal Antibodies |
Cancer, breast Cancer, breast, metastatic Cancer, gastrointestinal Cancer, stomach, metastatic |
|
BeiGene Jazz Pharmaceuticals Zymeworks (Originator) |
Pre-Registered |
Bispecific Antibodies Cancer Immunotherapy Humanized Monoclonal Antibodies |
Cancer Cancer, biliary Cancer, breast Cancer, endometrium Cancer, gastroesophageal junction (adenocarcinoma) Cancer, gastrointestinal Cancer, hepatobiliary Cancer, lung Cancer, ovary Cancer, solid tumor Cancer, stomach Cancer, stomach, metastatic Esophageal adenocarcinoma |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
Launched Drug Information Targeting HER2
Table 2. HER2-targeted drug information (launched).
| Company | Highest Phase | Product Category | Condition |
| Dr Reddy's Laboratories (Originator) | Launched - 2018 |
Cancer Immunotherapy Follow-on Products Humanized Monoclonal Antibodies Natural Products |
Cancer, breast Cancer, breast, metastatic Cancer, stomach, metastatic |
| Tanvex BioPharma (Originator) | Pre-Registered |
Cancer Immunotherapy Follow-on Products Humanized Monoclonal Antibodies |
Cancer, breast |
| SUNHO (China) BioPharmaceutical (Originator) | Phase II/III |
Cancer Immunotherapy Monoclonal Antibodies |
Cancer, colorectal, metastatic Cancer, solid tumor Digestive-gastrointestinal cancer |
| Shizuoka Cancer Center (Originator) | Phase II |
Cancer Immunotherapy Cancer Vaccines Dendritic Cell Therapy Dendritic Cell Vaccines |
Glioblastoma multiforme |
| Dragonfly Therapeutics (Originator) | Phase II |
Bispecific Antibody Fusions Cancer Immunotherapy Fc Fusion Proteins Polypeptides, from 41 AA |
Cancer, breast, metastatic Cancer, esophagus Cancer, lung (non-small cell) (NSCLC) Cancer, solid tumor |
| Triumvira (Originator) | Phase I/II | Cell Therapy |
Cancer, gastroesophageal junction Cancer, solid tumor Cancer, stomach |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
Creative Biolabs is dedicated to accelerating your research with our high-quality anti-HER2 recombinant antibodies. Please contact us to discover how our anti-HER2 recombinant antibodies can elevate your research. We are eager to collaborate with you and contribute to the success of your scientific endeavors.
Related Diseases
Breast Cancer
EGFR Tyrosine Kinase Inhibitor Resistance
Endocrine Resistance
- Anti-Human HER2 Recombinant Antibody Fab Fragment (Anti-HER2-IgGl) (TAB-0195CL-F(E))
-
- Type: Human antibody
- Application: FC, Cyt
Compare
- Anti-Human HER2 Recombinant Antibody scFv Fragment (Anti-HER2-IgGl) (TAB-0195CL-S(P))
-
- Type: Human antibody
- Application: FC, Cyt
Compare
- Anti-HER2 Antibody, Research Grade Biosimilar (TAB-785CL)
-
- Type: Antibody
Compare
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