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Anti-IL2 Recombinant Antibody Products

Anti-Il2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs offers a range of high-quality anti-IL2 recombinant antibody products to serve global customers in IL2-related basic research and therapeutic development. Our antibodies are carefully designed to precisely target IL2 and exhibit high sensitivity. Each of these antibodies undergoes rigorous quality control to ensure exceptional performance in customers' significant projects.

IL2: A Versatile Target for Cancer Therapy

IL-2 is a multifaceted cytokine with diverse effects on immune cells, ranging from promoting T cell proliferation and differentiation to influencing regulatory T cell function. Its pleiotropic nature, including both autocrine and paracrine actions, highlights the complexity of its biological roles. While IL-2's ability to stimulate cytotoxic effector cells has shown promise in cancer immunotherapy, its systemic administration often leads to significant side effects. Therefore, strategies aimed at targeting IL-2 signaling more precisely, such as through engineered IL-2 variants or cell-based delivery systems, are actively being explored to improve its therapeutic efficacy and minimize adverse events.

Alternative Names

IL-2; interleukin 2; TCGF; lymphokine.

Background

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Anti-IL2 rAb Products

Creative Biolabs offers a diverse collection of recombinant anti-IL2 antibodies meticulously engineered to exhibit high specificity and affinity. Our portfolio encompasses a range of antibody formats, including monoclonal antibodies, polyclonal antibodies, and antibody fragments, each tailored to specific research needs. These antibodies demonstrate exceptional performance across various applications, such as immunoprecipitation, WB, ELISA, flow cytometry, and immunohistochemistry. Leveraging our robust platform, we provide researchers and developers with cutting-edge tools to propel advancements in immunology, cancer biology, and related fields, facilitating the development of novel therapeutics targeting IL-2 signaling pathways.

Table 1. Featured anti-IL2 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
PABL-609 Mouse Anti-Il2 Recombinant Antibody (clone JES6-1) Mouse Mouse IgG FC, FuncS, IHC, ELISA
PABC-506 Human Anti-IL2 Recombinant Antibody (PABC-506) Human Human IgG1, λ Inhib, ELISA, FC, FuncS
ZG-0499J Mouse Anti-IL2 Recombinant Antibody (ZG-0499J) Human Mouse IgG WB, ELISA
HPAB-M0116-YC Mouse Anti-IL2 Recombinant Antibody (clone MAB602) Human, Mouse Mouse IgG ELISA, FC
HPAB-0112-YC Human Anti-IL2 Recombinant Antibody (HPAB-0112-YC) Human Human IgG1 WB, ELISA, FC, IHC

Creative Quality Control

Creative Biolabs offers a wide range of high-quality anti-IL2 recombinant antibodies that are meticulously developed with pinpoint accuracy, ensuring superior specificity and strong binding affinity. Our rigorous quality control and comprehensive validation data (such as binding kinetics and specificity analysis) provide researchers with the confidence to use these antibodies in a variety of research situations.

Fig.1 ELISA analysis. (Creative Biolabs Original)Fig.1 ELISA analysis of anti-IL2 antibody
(Cat# PABC-506, Creative Biolabs).

Fig.2 WB analysis. (Creative Biolabs Original)Fig.2 WB analysis of anti-IL2 antibody
(Cat# PABC-506, Creative Biolabs).

Fig.3 DB analysis. (Creative Biolabs Original)Fig.3 DB analysis of anti-IL2 antibody
(Cat# PABC-506, Creative Biolabs).

Fig.4 WB analysis. (Creative Biolabs Original)Fig.4 WB analysis of anti-IL2 antibody
(Cat# ZG-0499J, Creative Biolabs).

Fig.5 ELISA analysis. (Creative Biolabs Original)Fig.5 ELISA analysis of anti-IL2 antibody
(Cat# PABL-609, Creative Biolabs).

Fig.6 WB analysis. (Creative Biolabs Original)Fig.6 WB analysis of anti-IL2 antibody
(Cat# PABL-609, Creative Biolabs).

Customer Reviews

Excellent
Va***a
Human Anti-IL2 Recombinant Antibody (PABC-506) (PABC-506)
We incorporated Creative Biolabs' anti-IL2 antibody into our flow cytometry experiments to analyze IL2 expression on activated T cells. The antibody demonstrated strong binding affinity and specific recognition of IL2, enabling us to accurately quantify IL2 expression levels in different cell populations. The consistent performance of the antibody across multiple experiments significantly enhanced the reliability of our data and facilitated our understanding of IL2 dynamics in T cell activation.
26/Apr/2022
Excellent
Su***n
Human Anti-IL2 Recombinant Antibody (HPAB-0112-YC) (HPAB-0112-YC)
We recently utilized Creative Biolabs' anti-IL2 antibody for immunohistochemistry staining in mouse tissues. The antibody exhibited excellent specificity and sensitivity, resulting in clear and distinct staining of IL2-expressing cells. The background staining was minimal, and the signal-to-noise ratio was high. We were highly satisfied with the antibody's performance and its ability to provide valuable insights into IL2 expression patterns in our research.
9/Jun/2023
Excellent
Ma***y
Mouse Anti-IL2 Recombinant Antibody (ZG-0499J) (ZG-0499J)
We successfully used Creative Biolabs' anti-IL2 antibody for Western blot analysis of IL2 protein expression, which demonstrated excellent specificity and sensitivity, yielding a clear band at the expected molecular weight with minimal background interference. This high-quality antibody allowed us to accurately quantify IL2 protein levels in our samples, providing reliable and valuable data for our research.
11/Mar/2024

rAb Production

Creative Biolabs consistently delivers high-quality anti-IL2 antibodies produced using advanced genetic engineering techniques.

Featured Anti-IL2 Recombinant Antibody Production PlatformsFig.7 Milligram-scale. (Creative Biolabs Original)
Fig.7 Milligram-scale anti-IL2 recombinant antibody production.

Fig.8 Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-IL2 recombinant antibody production.

rAb Modalities

Creative Biolabs offers a diverse portfolio of high-quality anti-IL2 recombinant antibodies in various formats to cater to the diverse research needs of scientists worldwide.

Fig.9 IL2 antibody production and modalities. (Creative Biolabs Original)Fig.9 Full-length anti-IL2 recombinant antibody production and modalities.

IL2-Targeted Drug Information

Table 2. Public drug targeting IL2.

Company Research Phase Classification Condition
Ajinomoto
Alfa Wassermann
Citius Pharmaceuticals
Dr Reddy's Laboratories
Eisai
Ferrer
Friedrich-Alexander-Universitaet (Originator)
Ligand (Originator)
Lilly
MD Anderson Cancer Center
National Cancer Institute
Perrigo
Seragen (Ligand)
TSD Japan
Launched - 1999 Cancer Immunotherapy
Fusion Proteins
IL-2
Polypeptides, from 41 AA
Autoimmune disease
Cancer
Cancer, breast
Cancer, lung (non-small cell) (NSCLC)
Cancer, ovary (epithelial)
Cancer, pancreas, metastatic
Cancer, solid tumor
Chronic lymphocytic leukemia
Cutaneous T-cell lymphoma
Graft-versus-host disease
Leukemia-lymphoma, adult T-cell
Lymphoma
Lymphoma, diffuse large B-cell
Lymphoma, T-cell
Melanoma, metastatic
Non-Hodgkin lymphoma
Peripheral T-cell lymphoma
Psoriasis
Takeda (Originator) Launched - 1992 Cancer Immunotherapy
IL-2
Polypeptides, from 41 AA
Recombinant proteins
Angiosarcoma
Biogen (Originator)
Roche (Originator)
Shionogi
Launched - 1992 Cancer Immunotherapy
IL-2
Polypeptides, from 41 AA
Recombinant proteins
Angiosarcoma
Cancer, colorectal, metastatic
Children's Hospital of Philadelphia
Chiron (Novartis Vaccines and Diagnostics)
Clinigen
Hospital Universitario Puerta de Hierro (HUPH)
M.D. Anderson Cancer Center (MD Anderson Cancer Center)
National Cancer Institute
National Cancer Institute (NCI) (National Cancer Institute)
National Cancer Institute (US) (National Cancer Institute)
National Institute Allergy Infect Dis
Novartis (Originator)
Novartis Vaccines and Diagnostics (Originator)
Prometheus (Prometheus Biosciences)
University of Alabama at Birmingham
University of Pittsburgh
Launched - 1989 Cancer Immunotherapy
IL-2
Polypeptides, from 41 AA
Recombinant proteins
Acute coronary syndrome
Acute myeloid leukemia
Amyotrophic lateral sclerosis
Cancer, breast
Cancer, breast, metastatic
Cancer, kidney
Cancer, kidney, metastatic
Cancer, kidney (renal cell carcinoma)
Cancer, lung, metastatic
Cancer, lung (non-small cell) (NSCLC)
Cancer, metastatic (to lung)
Cancer, mouth
Cancer, ovary
Chronic myeloid leukemia
Cutaneous T-cell lymphoma
Diabetes type 1
Gastroesophageal reflux disease (GERD)
Graft-versus-host disease
Infection, HIV
Melanoma, intraocular
Melanoma, metastatic
Myelodysplasia
Myeloid leukemia
Neuroblastoma
Non-Hodgkin lymphoma
Transplant rejection
Wiskott-Aldrich syndrome
Biotech Ltd. (Originator) Launched Cancer Immunotherapy
IL-2
Polypeptides, from 41 AA
Recombinant proteins
Cancer
Immunological Disorders
Infections
Philogen (Originator)
Sun Pharma
Phase III Cancer Immunotherapy
Fusion Proteins
IL-2
Immunocytokines
Polypeptides, from 41 AA
Single-Chain V-Domain Antibody Fragment (scFv)
Tumor Necrosis Factor-alpha (TNF-alpha)
Cancer, skin
Cancer, skin (basal cell carcinoma)
Cancer, skin (squamous cell carcinoma)
Carcinoma, Merkel cell
Cutaneous T-cell lymphoma
Kaposi sarcoma
Melanoma
Peking University People's Hospital Phase III IL-2
Polypeptides, from 41 AA
Recombinant proteins
Behcet's disease
Dermatomyositis
Graft-versus-host disease
Inflammatory myopathy
Macrophage activation syndrome
Rheumatoid arthritis
Sjogren syndrome
Systemic lupus erythematosus
Innovent Biologics (Originator) Phase II Cancer Immunotherapy
Fusion Proteins
IL-2
Immunocytokines
Monoclonal Antibodies
Polypeptides, from 41 AA
Cancer
Cancer, solid tumor
Lymphoma
Melanoma
Second Xiangya Hosp Central South Univ (Originator) Phase II IL-2
Polypeptides, from 41 AA
Recombinant proteins
Pemphigus vulgaris
Urticaria
Merck & Co (Originator)
Merck & Co. (Merck & Co)
Pandion Therapeutics (Merck & Co)
Phase II Fc Fusion Proteins
IL-2
Polypeptides, from 41 AA
Atopic dermatitis
Autoimmune disease
Rheumatoid arthritis
Systemic lupus erythematosus
Ulcerative colitis
Vitiligo, non-segmental

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

As a senior leader in antibodies, Creative Biolabs possesses solid theoretical and production expertise and has successfully established an efficient antibody manufacturing process to ensure that high-quality anti-IL2 recombinant antibodies are generated within the customer's preferred time frame. If you are interested in our anti-IL2 recombinant antibodies, please contact us for a consultation.

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