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MRC1

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Protein class

CD markers, FDA approved drug targets, Plasma proteins

Predicted location

Membrane

Single cell type specificity

Group enriched (Hepatic stellate cells, Kupffer cells, Macrophages, Hofbauer cells, Breast glandular cells)

Immune cell specificity

Immune cell enriched (myeloid DC)

Cell line specificity

Group enriched (MOLT-4, TIME)

Interaction

(Microbial infection) Interacts with Dengue virus. (Microbial infection) May act as a receptor for hepatitis B virus, enabling uptake of the virus in hepatic dendritic cells.

Molecular function

Host cell receptor for virus entry, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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