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MYL2

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Protein class

Candidate cardiovascular disease genes, Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Cardiomyocytes)

Immune cell specificity

Group enriched (naive B-cell, memory B-cell)

Cell line specificity

Cell line enhanced (EFO-21, HSkMC, U-2 OS)

Interaction

Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with MYOC (PubMed:11773029).

Molecular function

Motor protein, Muscle protein, Myosin

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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