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PDX1
Anti-PDX1 Recombinant Antibody Products
- Mouse Anti-PDX1 Recombinant Antibody (clone 5A5) (VS3-QX864)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Mouse Anti-PDX1 Recombinant Antibody (clone 2G12) (VS3-XY1236)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
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- AbPlus™ Anti-PDX1 Magnetic Beads (VS-0724-YC1106) (VS-0724-YC1106)
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- Target: PDX1
- Target Species: Human
- Application: IP, Protein Purification
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC
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- CytoStream™ Mouse Anti-PDX1 Recombinant Antibody (VS-0225-XY175) (VS-0225-XY175)
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- Species Reactivity: Mouse, Human
- Type: Mouse IgG1, kappa
- Application: FC
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For Research Use Only. Not For Clinical Use.
PDX1 (Pancreatic and Duodenal Homeobox 1) encodes a transcription factor critical for pancreatic development and insulin regulation. It plays an essential role in the differentiation of pancreatic progenitor cells and the maintenance of insulin-producing beta cells. Mutations in PDX1 can lead to pancreatic dysfunction and have been linked to diseases like diabetes and pancreatic cancer.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cholangiocytes, Enteroendocrine cells, Ductal cells, Exocrine glandular cells, Gastric mucus-secreting cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HDLM-2, HEK93, HeLa, OE19)
Interaction
Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity). Interacts with the methyltransferase SETD7. Part of a PDX1:PBX1b:MEIS2b complex.
Molecular function
Activator, Developmental protein, DNA-binding
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Related Diseases
Type I Diabetes Mellitus