Anti-PRKAG1 Recombinant Antibody Products

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Anti-PRKAG1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs delivers high-specificity recombinant antibodies targeting PRKAG1, developed through cutting-edge engineering platforms to support critical metabolic and cardiovascular research. Our rigorously validated reagents demonstrate exceptional batch-to-batch consistency and application-specific performance across diverse experimental systems. The comprehensive product line combines scientific accuracy with cost-efficient solutions, facilitating studies from basic target validation to therapeutic development. Beyond premium antibody products, we offer personalized technical consultation and optimization support at every project stage. Collaborate with our scientific team to access expertly designed research tools and tailored solutions for your AMPK-related investigations.

PRKAG1: A Key Metabolic Regulator in Cardiac Diseases Cancer and Neurological Disorders

PRKAG1, a regulatory γ1 subunit of AMP-activated protein kinase, plays pivotal roles in cellular energy metabolism and stress response pathways. Dysregulation of this subunit contributes significantly to cardiac pathologies, particularly hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome, where glycogen accumulation in cardiomyocytes disrupts electrical conduction and contractile function. In metabolic disorders, impaired activity correlates with insulin resistance and abnormal lipid storage, exacerbating type 2 diabetes progression. Tumor microenvironments exploit its signaling to promote cancer cell survival under nutrient deprivation through autophagy induction and metabolic reprogramming. Neurological conditions including epilepsy may involve defective neuronal energy regulation due to altered subunit function. Recent evidence also suggests involvement in inflammatory pathways, potentially influencing autoimmune disease progression. The subunit's dual role as both metabolic sensor and regulator of mitochondrial biogenesis makes it particularly relevant in age-related degenerative diseases. While therapeutic targeting remains challenging due to systemic effects, modulating this pathway shows promise for treating conditions characterized by bioenergetic imbalance, particularly in cardiac and metabolic contexts. Pharmacological interventions require precise tissue-specific approaches to avoid disrupting its crucial housekeeping functions in normal physiology.

Alternative Names

Complement PRKAG1; AMPKG

Background

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.

Anti-PRKAG1 rAb Products

We empower metabolic and cardiovascular research through high-specificity anti-PRKAG1 antibodies that deliver exceptional batch-to-batch consistency, competitive pricing, and application-focused technical support. Our rigorously validated reagents enable reliable target detection across diverse experimental systems, from basic expression analysis to complex functional studies, while our scientific team provides tailored guidance to optimize your AMPK pathway investigations.

Customer Reviews

Excellent

C**ha
Rabbit Anti-PRKAG1 Recombinant Antibody (clone R08-7D5) (CAT#: VS3-FY1648)

The Rabbit Anti-PRKAG1 works well for IP in HEK293 lysates, effectively pulling down the target with clean background. We observed consistent performance across batches, though some optimization was needed for heart tissue lysates. While we haven't tested it extensively in other applications, it's proven reliable for our co-IP studies when paired with proper controls.

03/Feb/2024

Excellent

Ja**a
Recombinant Rabbit Anti-PRKAG1 Monoclonal Antibody (DS2849AB) (CAT#: MOR-2849)

The Anti-PRKAG1 performs well in WB with clear detection of the expected band in HEK293T lysates. We noticed slight non-specific bands in liver tissue samples that required increased blocking time. While it's slightly more expensive than standard options, the batch-to-batch consistency has been good for our basic protein expression studies.

12/Aug/2024

rAb Production

With extensive experience in engineered antibody development, we deliver premium-grade recombinant antibodies through optimized processes that balance speed and quality. Our streamlined production ensures reliable reagents with accelerated turnaround times.

Featured Anti-PRKAG1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-PRKAG1 recombinant antibody production.

Fig.2 Gram-scale anti-PRKAG1 recombinant antibody production.

rAb Modalities

Creative Biolabs specializes in providing premium engineered antibodies across multiple formats, leveraging cutting-edge molecular design technologies. Our expertise spans diverse antibody development platforms to deliver customized solutions for unique research requirements. In addition to standard offerings, we provide tailored modification services to optimize antibody performance for specialized applications.

Fig.3 Full Length Anti-PRKAG1 Recombinant Antibody Production and Modalities.

For PRKAG1-related inquiries, our technical specialists are available to provide expert consultation. Researchers may contact us through standard channels for assistance with experimental optimization or troubleshooting needs. We're committed to supporting your investigation with tailored solutions throughout your research process.