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RTN4R

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Protein class

Disease related genes, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Excitatory neurons, Bipolar cells, Muller glia cells)

Immune cell specificity

Immune cell enhanced (MAIT T-cell)

Cell line specificity

Cell line enhanced (NB-4, REH, SCLC-21H, SK-MEL-30)

Interaction

Homodimer (PubMed:18411262). Interacts with MAG (PubMed:12089450, 12839991, 18411262, 19052207). Interacts with RTN4 (PubMed:12839991, 19052207). Interacts with NGFR (PubMed:12426574, 18411262, 19052207). Interacts with LINGO1 (PubMed:14966521, 19052207). Interacts with KIAA0319L (PubMed:20697954). Interacts with OLFM1; this inhibits interaction with LINGO1 and NGFR (By similarity). Interacts with OMG (PubMed:12068310, 12839991, 19052207).

Molecular function

Receptor

More Types Infomation

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