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SHC4

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For Research Use Only. Not For Clinical Use.


Protein class

RAS pathway related proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Astrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (AN3-CA, SK-MEL-30, WM-115)

Interaction

Interacts (via PID domain) with phosphorylated MUSK (via NPXY motif); undergoes tyrosine phosphorylation downstream of activated MUSK. Interacts with GRB2; the interaction is dependent of Tyr-424 phosphorylation and increased by EGF.

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