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    TNFRSF17

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    • Anti-BCMA (clone 2A1)-PEG4-Mal-DM4 ADC (ADC-152CL)
      • Target: BCMA (B-Cell Maturation Antigen)
      • Linker: PEG4-Mal
      • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    • Anti-BCMA (clone 2A1CV5)-SMCC-DM1 ADC (ADC-153CL)
      • Target: BCMA (B-Cell Maturation Antigen)
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-BCMA (clone 2A1CV4)-SMCC-DM1 ADC (ADC-154CL)
      • Target: BCMA (B-Cell Maturation Antigen)
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-BCMA (clone 1E1)-SMCC-DM1 ADC (ADC-155CL)
      • Target: BCMA (B-Cell Maturation Antigen)
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
      Go to compare Compare
    • Anti-BCMA (clone 1E1)-PEG4-Mal-DM4 ADC (ADC-156CL)
      • Target: BCMA (B-Cell Maturation Antigen)
      • Linker: PEG4-Mal
      • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
      Go to compare Compare
    • Anti-BCMA (clone 2A1)-SMCC-DM1 ADC (ADC-151CL)
      • Target: BCMA (B-Cell Maturation Antigen)
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-BCMA-mc-MMAF ADC (ADC-043LZY)
      • Target: BCMA
      • Linker: mc (maleimidocaproyl)
      • Drug: MMAF (monomethyl auristatin F)
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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
    Protein class

    Cancer-related genes, CD markers, Disease related genes

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enriched (Plasma cells)

    Immune cell specificity

    Group enriched (memory B-cell, naive B-cell, plasmacytoid DC)

    Cell line specificity

    Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)

    Interaction

    Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.

    Molecular function

    Receptor

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