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Timd4

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For Research Use Only. Not For Clinical Use.


Enables phosphatidylserine binding activity. Acts upstream of or within apoptotic cell clearance. Predicted to be located in membrane. Is expressed in aorta-gonad-mesonephros; brain; gonad; liver; and lung. Used to study systemic lupus erythematosus. Orthologous to human Timd4 (T cell immunoglobulin and mucin domain containing 4).
Protein class

Plasma proteins

Predicted location

Membrane

Single cell type specificity

Group enriched (Late spermatids, Early spermatids)

Immune cell specificity

Group enriched (T-reg, memory CD8 T-cell, naive CD8 T-cell, naive CD4 T-cell, memory CD4 T-cell)

Cell line specificity

Group enriched (U-266/70, U-266/84)

Interaction

Interacts with MERTK; this interaction enhances TIMD4-mediated efferocytosis (PubMed:32640697). Interacts with EPHA2 (PubMed:34067457).

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