Mouse Anti-TIMD4 Recombinant Antibody (clone 2A1H5)

CAT#: VS7-0425-WR992

This product is a mouse IgG1 antibody that binds to human TIMD4. The antibody 2A1H5 recognizes specific amino acid domain of human TIMD4 (AA: extra 25-314). It can be used for WB and FC assays.

Gene Expression
Figure 1 IF staining of human cell line A549 Figure 2 IHC staining of human lymph node Figure 3 IHC staining of human tonsil Figure 4 Colon Figure 5 Kidney Figure 6 Testis Figure 7 RNA cell line category: Group enriched (U-266/70, U-266/84)

Specifications

  • Immunogen
  • Recombinant human TIMD4 (AA: extra 25-314) fragment expressed in E. Coli.
  • Host Species
  • Mouse
  • Type
  • Mouse IgG1
  • Specificity
  • Human TIMD4
  • Species Reactivity
  • Human
  • Clone
  • 2A1H5
  • Molecule Class
  • Plasma Proteins
  • Conjugate
  • Unconjugated

Product Property

  • Clonality
  • Monoclonal
  • Purity
  • >95% as determined by SDS-PAGE and SEC-HPLC analysis
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • 0.05% sodium azide
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • Western Blot: 1:500 - 1:2000
    Flow Cytometry: 1:200 - 1:400
    Enzyme-linked Immunosorbent Assay: 1:10000

Target

  • Alternative Names
  • T Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin Mucin Receptor 4; T-Cell Membrane Protein 4; TIMD-4; TIM-4; TIM4; T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4; SMUCKLER
  • Long Name
  • T Cell Immunoglobulin And Mucin Domain Containing 4
  • Cellular Localization
  • Cell membrane; Membrane; Secreted
  • Post Translation Modifications
  • Disulfide bond; Glycoprotein; Phosphoprotein
  • Function
  • Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity).; Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:32703939, PubMed:34067457).; Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (PubMed:32640697).; Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (By similarity).
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

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Isotype Control

Secondary Antibody

Reconstitution Buffer

Recommended Dilution Buffer

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