Mouse Anti-TIMD4 Recombinant Antibody (clone 2A1H5)
CAT#: VS7-0425-WR992
This product is a mouse IgG1 antibody that binds to human TIMD4. The antibody 2A1H5 recognizes specific amino acid domain of human TIMD4 (AA: extra 25-314). It can be used for WB and FC assays.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15625/1873_G5_4_selected.jpg
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Specifications
- Immunogen
- Recombinant human TIMD4 (AA: extra 25-314) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human TIMD4
- Species Reactivity
- Human
- Clone
- 2A1H5
- Molecule Class
- Plasma Proteins
- Applications
- WB, FC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- T Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin Mucin Receptor 4; T-Cell Membrane Protein 4; TIMD-4; TIM-4; TIM4; T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4; SMUCKLER
- Gene ID
- 91937
- UniProt ID
- Q96H15
- Long Name
- T Cell Immunoglobulin And Mucin Domain Containing 4
- Cellular Localization
- Cell membrane; Membrane; Secreted
- Post Translation Modifications
- Disulfide bond; Glycoprotein; Phosphoprotein
- Protein Refseq
- NP_001140198.1
- Function
- Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity).; Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:32703939, PubMed:34067457).; Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (PubMed:32640697).; Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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Secondary Antibody
- CAT
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Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "Timd4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2028CQ | Rat Anti-Timd4 Recombinant Antibody (clone RMT4-53) | FC, ICC, IF, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2029CQ | Rat Anti-Timd4 Recombinant Antibody (clone RMT4-54) | FC, FuncS, Block | Rat IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3571 | Rabbit Anti-Timd4 Recombinant Antibody (clone DS3571AB) | ELISA | Rabbit IgG |
| MOR-4457 | Rabbit Anti-TIMD4 Recombinant Antibody (clone SI551DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0010-FY | Hamster Anti-TIMD4 Recombinant Antibody (clone Kat5-18) | FC, FuncS, IA, IF | Hamster IgG |
| FAMAB-1302CQ | Mouse Anti-TIMD4 Recombinant Antibody (clone 5G3) | FC, WB, ELISA | Mouse IgG2a |
| FAMAB-1304CQ | Mouse Anti-TIMD4 Recombinant Antibody (clone 3A1) | ELISA, FC | Mouse IgG2a |
| VS3-FY2895 | Mouse Anti-TIMD4 Recombinant Antibody (VS3-FY2895) | WB, FC, ELISA, ICC | Mouse IgG |
| VS7-0425-WR991 | Mouse Anti-TIMD4 Recombinant Antibody (clone 2C6A3) | ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2292 | Anti-TIMD4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7259 | Anti-Mouse TIMD4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC706 | Recombinant Anti-Timd4 Vesicular Antibody, EV Displayed (VS-0425-YC706) | ELISA, FC, Cell-uptake |
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