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YWHAB
Anti-YWHAB Recombinant Antibody Products
- Rabbit Anti-YWHAB Recombinant Antibody (clone CBACN-001) (MRO-0001-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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- Rabbit Anti-YWHAB Recombinant Antibody (clone CBACN-002) (MRO-0002-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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- Rabbit Anti-YWHAB Recombinant Antibody (clone SD0837) (MRO-0003-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
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- Mouse Anti-YWHAB Recombinant Antibody (clone 9-26) (MRO-0004-CN)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Mouse IgG2a
- Application: WB, IF, IHC
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- AbPlus™ Anti-YWHAB Magnetic Beads (VS-0724-YC1491) (VS-0724-YC1491)
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- Target: YWHAB
- Target Species: Cynomolgus
- Application: IP, Protein Purification
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- Rabbit Anti-YWHAB Polyclonal Antibody (MRO-1619-CN) (MRO-1619-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- AbPlus™ Anti-YWHAB Magnetic Beads (SD0837) (VS-0424-XY278)
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- Target: YWHAB
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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- AbPlus™ Anti-YWHAB Magnetic Beads (VS-0724-YC1440) (VS-0724-YC1440)
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- Target: YWHAB
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:17717073). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13 (PubMed:21224381). Interacts with SSH1 and TORC2/CRTC2 (PubMed:15454081, PubMed:15159416). Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159). Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073). Interacts with GAB2 (PubMed:19172738). Interacts with YAP1 (phosphorylated form) (PubMed:17974916). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with MYO1C (PubMed:24636949). Interacts with SIRT2 (PubMed:18249187). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (PubMed:22827337). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381). Interacts with SLITRK1 (PubMed:19640509). Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form) isoform 2; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844). Interacts with MARK2 and MARK3 (PubMed:16959763). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-437' and inhibits TESK1 kinase activity (PubMed:11555644). Interacts with MEFV (PubMed:27030597). (Microbial infection) Interacts with herpes simplex virus 1 protein UL46. (Microbial infection) Probably interacts with Chlamydia trachomatis protein IncG.
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