Anti-YWHAB Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs offers top-tier recombinant anti-YWHAB antibody products, meticulously crafted to help researchers and pharmaceutical developers with their work. Our focus on innovation and quality guarantees exceptional performance, driving progress in biological and medical research globally.

YWHAB: A Multifaceted Target for Cancer and Neurodegenerative Therapies

YWHAB, also known as 14-3-3 beta, is a highly conserved adapter protein involved in critical cellular processes like signal transduction, cell cycle regulation, and apoptosis. Recent research highlights its aberrant expression in various cancers, including colon and breast cancer, where it correlates with tumor invasiveness and poor prognosis. Moreover, YWHAB dysregulation is implicated in neurodegenerative conditions. Understanding YWHAB's roles is vital for developing novel diagnostic biomarkers and targeted therapeutic strategies for these complex diseases.

Alternative Names

14-3-3 protein beta/alpha; GW128; HEL-S-1; HS1; KCIP-1; YWHAA; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta.

Background

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Homodimer (PubMed:17717073). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13 (PubMed:21224381). Interacts with SSH1 and TORC2/CRTC2 (PubMed:15454081, PubMed:15159416). Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159). Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073). Interacts with GAB2 (PubMed:19172738). Interacts with YAP1 (phosphorylated form) (PubMed:17974916). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with MYO1C (PubMed:24636949). Interacts with SIRT2 (PubMed:18249187). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (PubMed:22827337). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381). Interacts with SLITRK1 (PubMed:19640509). Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form) isoform 2; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844). Interacts with MARK2 and MARK3 (PubMed:16959763). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-437' and inhibits TESK1 kinase activity (PubMed:11555644). Interacts with MEFV (PubMed:27030597). (Microbial infection) Interacts with herpes simplex virus 1 protein UL46. (Microbial infection) Probably interacts with Chlamydia trachomatis protein IncG.

More Types Infomation

Anti-YWHAB rAb Products

Creative Biolabs' recombinant anti-YWHAB antibodies are engineered with superior specificity and affinity, ensuring precise detection and modulation of the YWHAB protein. Produced using our proprietary recombinant technology, these antibodies offer exceptional batch-to-batch consistency and purity, minimizing experimental variability. Their high performance in diverse applications makes them indispensable tools for both fundamental research and preclinical studies.

Cat. No. Product Name Target Species Host Species Applications
VS3-FY1570 Recombinant Rabbit Anti-YWHAB Antibody (clone R08-4A7) Human, Mouse, Rat Rabbit IgG WB, IHC-P, IP
MRO-0001-CN Rabbit Anti-YWHAB Recombinant Antibody (clone CBACN-001) Human, Mouse, Rat Rabbit IgG WB, IHC
MRO-0003-CN Rabbit Anti-YWHAB Recombinant Antibody (clone SD0837) Human, Mouse, Rat Rabbit IgG WB, IF, IHC, IP, FC
MRO-1619-CN Rabbit Anti-YWHAB Polyclonal Antibody (MRO-1619-CN) Human, Mouse, Rat Rabbit IgG WB, IF, IHC
VS3-FY1570 Recombinant Rabbit Anti-YWHAB Antibody (clone R08-4A7) Human, Mouse, Rat Rabbit IgG WB, IHC-P, IP

Creative Quality Control

Our commitment to excellence is reflected in our rigorous quality control for anti-YWHAB recombinant antibodies. Each batch undergoes comprehensive validation, including ELISA, Western Blot, and immunofluorescence assays, to confirm specificity, sensitivity, and optimal performance. This stringent quality assurance process guarantees reliable and reproducible results for your critical research applications.

WB analysis. (Creative Biolabs Original)Fig.1 WB analysis of anti-YWHAB antibody
(Cat# VS3-FY1570, Creative Biolabs).

Customer Reviews

Excellent
Va***i
Recombinant Rabbit Anti-YWHAB Antibody (clone 6F6) (VS4-CJ156)
The anti-YWHAB recombinant antibody from Creative Biolabs significantly enhanced our experiments. Its consistent performance saved us valuable time, delivering clear, reproducible data in Western blot analyses. The high specificity meant no cross-reactivity, which is crucial for our complex oncology studies. Truly an outstanding product!
17/Dec/2024
Excellent
La***Y
Recombinant Rabbit Anti-YWHAB Antibody (clone 6F6) (VS4-CJ156)
We've been thoroughly impressed with the anti-YWHAB antibody's performance in our neurodegenerative models. It provided strong, clean signals in immunofluorescence, allowing us to accurately visualize protein localization. This antibody has become an essential reagent in our lab, consistently yielding reliable results for our challenging research.
21/Jan/2025
Excellent
Br***n
Recombinant Mouse Anti-Rat YWHAB Antibody (clone 5F2) (MOB-2171MZ)
This anti-YWHAB recombinant antibody is a game-changer for our drug screening efforts. Its high binding affinity and excellent stability have greatly improved the efficiency of our ELISA-based assays. We appreciate the consistent quality, which ensures the integrity of our high-throughput screening results and accelerates our therapeutic development pipelines.
11/Jun/2025

rAb Production

The production of our anti-YWHAB recombinant antibodies leverages state-of-the-art expression systems and purification techniques. This advanced manufacturing process ensures high yields of antibodies with exceptional purity and lot-to-lot consistency, free from animal-derived components, thereby minimizing potential contaminants and enhancing experimental reproducibility.

Featured Anti-YWHAB Recombinant Antibody Production PlatformsMilligram-scale. (Creative Biolabs Original)
Fig.2 Milligram-scale anti-YWHAB recombinant antibody production.

Gram-scale. (Creative Biolabs Original)Fig.3 Gram-scale anti-YWHAB recombinant antibody production.

rAb Modalities

Our anti-YWHAB recombinant antibodies are available in multiple modalities, including conjugated and unconjugated forms, providing versatile options to suit various experimental needs and applications.

YWHAB antibody production and modalities. (Creative Biolabs Original)Fig.4 Full-length anti-YWHAB recombinant antibody production and modalities.

Creative Biolabs is dedicated to supporting your scientific endeavors with premium-grade recombinant antibody solutions. We invite you to explore our comprehensive catalog of anti-YWHAB recombinant antibody products. For detailed information, technical support, or to discuss custom requirements, please do not hesitate to contact us directly. Our expert team is ready to assist you in advancing your research.

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