uPAcs-Luffin-β immunotoxin
CAT#: AGTO-L071L
This immunotoxin was achieved by conjugating/fusing the uPAcs to loofah toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to lung cancer cells and the toxin enters cells by receptor-mediated endocytosis. Then loofah toxin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of lung cancer.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1789_A4_1_cr5bacc2acbd568_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_2_7_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1886_D2_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1819_G1_4_cr5bacc1ca11170_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_B_9_5.jpg
Normal Tissue
Figure 6 Colon
Endocrine cells
Staining:Medium
Intensity: Moderate
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Fibroblasts
Staining:High
Intensity: Strong
Goblet cells
Staining:Low
Intensity: Moderate
Quantity: <25%
Mucosal lymphoid cells
Staining:High
Intensity: Strong
Quantity:>75%
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_8_3.jpg
Normal Tissue
Figure 7 Kidney
Bowman's capsule
Staining:Medium
Intensity: Moderate
Quantity:>75%
Collecting ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Distal tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Proximal tubules (microvilli)
Staining:Medium
Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_5_6.jpg
Normal Tissue
Figure 9 Prostate
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_2_5.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, LHCN-M2, RPTEC TERT1, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122861-PLAU
❮
❯
Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- uPAcs-Luffin-β
- Toxin Description
- Loofah toxin (Luffin-β), is separated from the silk seeds into type I ribosome inactivating protein (ribosomeinactivating protein, RIP), RIP gourd. There are many types, mainly Luffin-a, Luffin-β, Luffin-Ss, Luffin-cylin, Luffin-Pl, which Luffin-β point containing 278 amino acids, the molecular weight of 30. 583KD, etc. 9.5, capable of specifically hydrolyzing eukaryotic ribosomes 28SrRNA4324 bit of adenine, so true 60s nuclear large subunit of ribosomes inactivate significantly inhibit protein synthesis, is one of the most active single-chain RIP are currently in, is of concern immunotoxin new powerful warhead small molecule recent years
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Lung cancer
Target
- Alternative Names
- ATF; BDPLT5; EC 3.4.21.73; PLAU; QPD; U plasminogen activator; u-PA; UPA; UPAM; Urinary plasminogen activator; URK; Urokinase plasminogen activator; Urokinase type plasminogen activator; Lung cancer; small-cell lung carcinoma; SCLC; Loofah toxin; Loofah; Luffin-β; Luffin B; Luffin
- Gene ID
- 5328
- UniProt ID
- P00749
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
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• Animal-free production
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Datasheet
MSDS
COA
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