uPAcs-Luffin-β immunotoxin (CAT#: AGTO-L071L)
This immunotoxin was achieved by conjugating/fusing the uPAcs to loofah toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to lung cancer cells and the toxin enters cells by receptor-mediated endocytosis. Then loofah toxin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of lung cancer.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RPTEC TERT1
(Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1789_A4_1_cr5bacc2acbd568_selected.jpg
(Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1789_A4_1_cr5bacc2acbd568_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_2_7_selected.jpg
(Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_2_7_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1886_D2_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1886_D2_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1819_G1_4_cr5bacc1ca11170_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1819_G1_4_cr5bacc1ca11170_blue_red_green.jpg
Figure 5 Cerebral cortex
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_B_9_5.jpg
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_B_9_5.jpg
Figure 6 Colon
(Endocrine cells
Staining:Medium
Intensity: Moderate
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Fibroblasts
Staining:High
Intensity: Strong
Goblet cells
Staining:Low
Intensity: Moderate
Quantity: <25%
Mucosal lymphoid cells
Staining:High
Intensity: Strong
Quantity:>75%
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_8_3.jpg
(Endocrine cells
Staining:Medium
Intensity: Moderate
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Fibroblasts
Staining:High
Intensity: Strong
Goblet cells
Staining:Low
Intensity: Moderate
Quantity: <25%
Mucosal lymphoid cells
Staining:High
Intensity: Strong
Quantity:>75%
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_8_3.jpg
Figure 7 Kidney
(Bowman's capsule
Staining:Medium
Intensity: Moderate
Quantity:>75%
Collecting ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Distal tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Proximal tubules (microvilli)
Staining:Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_9_5.jpg
(Bowman's capsule
Staining:Medium
Intensity: Moderate
Quantity:>75%
Collecting ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Distal tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Proximal tubules (microvilli)
Staining:Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_9_5.jpg
Figure 8 Testis
(Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_5_6.jpg
(Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_5_6.jpg
Figure 9 Prostate
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_2_5.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_2_5.jpg
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, LHCN-M2, RPTEC TERT1, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122861-PLAU
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122861-PLAU
Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- uPAcs-Luffin-β
- Toxin Description
- Loofah toxin (Luffin-β), is separated from the silk seeds into type I ribosome inactivating protein (ribosomeinactivating protein, RIP), RIP gourd. There are many types, mainly Luffin-a, Luffin-β, Luffin-Ss, Luffin-cylin, Luffin-Pl, which Luffin-β point containing 278 amino acids, the molecular weight of 30. 583KD, etc. 9.5, capable of specifically hydrolyzing eukaryotic ribosomes 28SrRNA4324 bit of adenine, so true 60s nuclear large subunit of ribosomes inactivate significantly inhibit protein synthesis, is one of the most active single-chain RIP are currently in, is of concern immunotoxin new powerful warhead small molecule recent years
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Lung cancer
Target
- Alternative Names
- ATF; BDPLT5; EC 3.4.21.73; PLAU; QPD; U plasminogen activator; u-PA; UPA; UPAM; Urinary plasminogen activator; URK; Urokinase plasminogen activator; Urokinase type plasminogen activator; Lung cancer; small-cell lung carcinoma; SCLC; Loofah toxin; Loofah; Luffin-β; Luffin B; Luffin
- Gene ID
- 5328
- UniProt ID
- P00749
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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