Anti-GCC (clone 5F9)-vc-MMAE ADC (CAT#: ADC-260CL)

• Antibody Overview
• Anti-GCC Antibody 5F9

• Clone
• 5F9

• Linker
• VC (valine-citrulline)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.
  Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain. The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.

• Alternative Names
• GUCY2C; guanylate cyclase 2C; STAR; DIAR6; GUC2C; MECIL; MUCIL; heat-stable enterotoxin receptor; GC-C; hSTAR; STA receptor; guanylyl cyclase C; intestinal guanylate cyclase; heat stable enterotoxin receptor;

• Gene ID
• 2984

• UniProt ID
• P25092

• ADC-262CL
• Anti-GCC (clone 5F9)-mc-MMAF ADC

• ADC-121LCT
• Anti-GCC (5F9)-Cleavable peptide linker-MMAE ADC

• ADC-049LZY
• Anti-Guanylyl cyclase C (clone 5F9)-vc-MMAE ADC

• ADC-L035
• Anti-GCC (5F9)-mc-val-cit-PABC-MMAE ADC (MLN0264)

Select a product category from the dropdown menu below to view related products.