Anti-5T4 (clone A1)-SMCC-DMA ADC (CAT#: ADC-006CL)

• Antibody Overview
• A1 (a Humanized Anti-5T4 lgG1 Antibody)

• Clone
• A1

• Antibody Isotype
• lgG1

• Linker
• SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)

• Linker Class/Description
• Class: Noncleavable linkers
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• DMA

• Introduction
• This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

• Alternative Names
• TPBG; trophoblast glycoprotein; 5T4; M6P1; 5T4AG; WAIF1; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; 5T4 oncofetal trophoblast glycoprotein;

• Gene ID
• 7162

• UniProt ID
• Q13641

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