Anti-5T4 (clone A1)-AcBut-calicheamicin ADC (CAT#: ADC-009CL)

• Antibody Overview
• A1-lgG4 (a Humanized Anti-5T4 lgG4 Antibody)

• Clone
• A1

• Antibody Isotype
• lgG4

• Linker
• AcBut (4-(4'acetylphenoxy)butanoic acid)

• Linker Class/Description
• Class: Chemically cleavable linkers-Acid-labile linkers
  Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.

• Drug
• calicheamicin

• Drug Class/Description
• Class: Calicheamicin
  Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

• Introduction
• This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

• Alternative Names
• TPBG; trophoblast glycoprotein; 5T4; M6P1; 5T4AG; WAIF1; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; 5T4 oncofetal trophoblast glycoprotein;

• Gene ID
• 7162

• UniProt ID
• Q13641

• ADC-001CL
• Anti-5T4 (clone A1)-mc-MMAF ADC

• ADC-002CL
• Anti-5T4 (clone A1)-vc-MMAE ADC

• ADC-003CL
• Anti-5T4 (clone A1)-vc-MMAD ADC

• ADC-006CL
• Anti-5T4 (clone A1)-SMCC-DMA ADC

• ADC-002LCT
• Anti-5T4 (A1)-Maleimido (Non-Cleavable) oxime PEG-MMAD ADC

• ADC-005LCT
• Anti-5T4 (A1)-hydroxyl amino PEG-MMAD ADC

Select a product category from the dropdown menu below to view related products.