Anti-5T4 (clone A1)-AcBut-calicheamicin ADC
CAT#: ADC-009CL
This ADC product is composed of an anti-5T4 antibody (clone A1) conjugated via AcBut linker to calicheamicin(A1-lgG4-AcBut calicheamicin (A1-IGG4-CM)). It has demonstrated a response in 5T4-positive cancer treatment.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/if_selected.jpg
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Specifications
- Antibody Overview
- A1-lgG4 (a Humanized Anti-5T4 lgG4 Antibody)
- Clone
- A1
- Antibody Isotype
- lgG4
- Linker
- AcBut (4-(4'acetylphenoxy)butanoic acid)
- Linker Class/Description
- Class: Chemically cleavable linkers-Acid-labile linkers
Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.
- Drug
- calicheamicin
- Drug Class/Description
- Class: Calicheamicin
Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.
Target
- Introduction
- This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
- Alternative Names
- TPBG; trophoblast glycoprotein; 5T4; M6P1; 5T4AG; WAIF1; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; 5T4 oncofetal trophoblast glycoprotein;
- Gene ID
- 7162
- UniProt ID
- Q13641
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Datasheet
MSDS
COA
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See other products for "Clone A1"
- CAT
- Product Name
See other products for "TPBG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-118-F(E) | Anti-Human 5T4 Recombinant Antibody Fab Fragment, 5T4 (TAB-118-F(E)) | FuncS, IF, Neut, ELISA, FC, IP, ICC | Fab - G1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1796MZ | Recombinant Mouse Anti-Human TPBG Antibody (clone 3D6) | ELISA, WB | Mouse antibody |
| HPAB-0287-WJ | Rabbit Anti-TPBG Recombinant Antibody (HPAB-0287-WJ) | ELISA, FC | Rabbit IgG |
| ZG-0047U | Rabbit Anti-TPBG Recombinant Antibody (clone 6E9) | ELISA, WB, IHC | Rabbit IgG |
| VS3-WK949 | Rabbit Anti-TPBG Recombinant Antibody (VS3-WK949) | WB, IP | Rabbit IgG |
| VS4-CJ140 | Recombinant Human Anti-TPBG Antibody (clone 13C3) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3649 | Rabbit Anti-TPBG Recombinant Antibody (clone DS3649AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0088CQ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0088CQ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0089CQ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0089CQ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0287-WJ-S(P) | Rabbit Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0287-WJ-S(P)) | ELISA, FC | Rabbit scFv |
| HPAB-0288-WJ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0288-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0645-WJ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0645-WJ-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0088CQ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0088CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0089CQ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0089CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0090CQ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0090CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0091CQ-F(E) | Mouse Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0091CQ-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0645-WJ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0645-WJ-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1281 | PE-H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-CN1282 | APC-H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-CN1283 | FITC-H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-YF748 | H-2Db/Human TPBG (ASFRNLTHL) MHC Pentamer | FCM | |
| MHC-YF755 | A*02:01/Human Trophoblast glycoprotein (RLARLALVL) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY114 | Human Anti-TPBG (clone ASN004) scFv-Fc Chimera | ELISA, FC, FuncS | Human IgG1, scFv-Fc |
| VS-0425-FY60 | Human Anti-TPBG (clone H8) scFv-Fc Chimera | FC, ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC638 | Recombinant Anti-TPBG Vesicular Antibody, EV Displayed (VS-0425-YC638) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7454 | Anti-TPBG Immunohistochemistry Kit | IHC | |
| VS-0525-XY7455 | Anti-Mouse TPBG Immunohistochemistry Kit | IHC |
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