Human Anti-ANG Recombinant Antibody (clone 26-2F) (CAT#: PABL-008)
Recombinant Human Antibody (26-2F) is capable of binding to ANG, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ANG mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-ANG mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
IHC
Figure 1 IHC detection of human and mouse ANG in normal and cancer tissues.
Human ANG was detected by 26-2F, Mouse ANG was detected by an affinity-purified polyclonal antibody.
Li, S., & Hu, G. F. (2010). Angiogenin-mediated rRNA transcription in cancer and neurodegeneration. International journal of biochemistry and molecular biology, 1(1), 26.
FuncS
Figure 2 Survivor functions showing prevention of HT-29 tumor growth in athymic mice by treatment with Ang antagonists.
On day 0 HT-29 cells (1.25 X 10⁵ per mouse) are mixed with PBS or the Ang antagonist and injected s.c. Daily injections of PBS or the Ang antagonist are then given for the next 35 days. (A) …, PBS (n = 145); —, mAb 26-2F (60 ,ug; n = 20); - -, mAb 36u (60 μg; n = 41); ---, mAb 26-2F + mAb 36u (30 μg of each; n = 47). (B)..., PBS (n = 145); -, bovine actin (18 μg; n = 28).
Olson, K. A., Fett, J. W., French, T. C., Key, M. E., & Vallee, B. L. (1995). Angiogenin antagonists prevent tumor growth in vivo. Proceedings of the National Academy of Sciences, 92(2), 442-446.
Specifications
- Immunogen
- Human angiogenin
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG1, κ
- Specificity
- Human ANG
- Species Reactivity
- Human
- Clone
- 26-2F
- Applications
- WB, IHC, IF, FuncS
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody 26-2F has been reported in applications of Western Blot, Immunohistochemistry, Immunofluorescence, Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
Fab Fragment Antibody
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-64 | Recombinant Anti-human ANG Antibody | ELISA, IP, FuncS | IgG |
| MHH-64 | Recombinant Human Anti-human ANG Antibody | WB, Neut, FuncS | IgG |
| MOB-0614MZ | Mouse Anti-ANG Recombinant Antibody (clone 25028.8) | ELISA, IHC-Fr, IHC-P, WB | Mouse IgG1 |
| MOB-321YJL | Mouse Anti-ANG Recombinant Antibody (clone 26-2F) | ELISA, ICC, IF, IHC-P, IHC-Fr, IP | Mouse IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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