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ANG
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Immune cell enhanced (classical monocyte, myeloid DC)
Cell line specificity
Group enriched (Hep G2, OE19)
Interaction
Homodimer (PubMed:25372031). Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.
Molecular function
Developmental protein, DNA-binding, Endonuclease, Hydrolase, Nuclease, Protein synthesis inhibitor
More Types Infomation
- Recombinant Anti-human ANG Antibody (MOB-64)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IP, FuncS
- Recombinant Anti-human ANG Antibody scFv Fragment (MOB-64-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, IHC, FuncS
- Recombinant Human Anti-human ANG Antibody Fab Fragment (MHH-64-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: Neut, WB, FuncS
- Recombinant Anti-human ANG Antibody Fab Fragment (MOB-64-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: RIA, WB, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, Neut, FuncS
- Mouse Anti-ANG Recombinant Antibody (clone 26-2F) (MOB-321YJL)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, ICC, IF, IHC-P, IHC-Fr, IP
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, IHC, IF, FuncS
- Mouse Anti-ANG Recombinant Antibody (clone 25028.8) (MOB-0614MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IHC-Fr, IHC-P, WB
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: WB, IHC, IF, FuncS
- Recombinant Human Anti-human ANG Antibody scFv Fragment (MHH-64-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: FC, Neut, Biosensors, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, IHC, IF, FuncS
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For Research Use Only. Not For Clinical Use.