Afuco™ Anti-Human APCS ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-045CL)
Anti-APCS ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. Anti-SAP antibody treatment is clinically feasible because circulating human SAP can be depleted in patients by the bis-D-proline compound, CPHPC4, thereby enabling injected anti-SAP antibodies to reach residual SAP in the amyloid deposits. The unprecedented capacity of this novel combined therapy to eliminate amyloid deposits should be applicable to all forms of systemic and local amyloidosis.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/ihc_selected.jpg
Figure 2 IHC staining of human soft tissue
(Immunohistochemical staining of human soft tissue shows positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7817/ihc_selected.jpg
(Immunohistochemical staining of human soft tissue shows positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7817/ihc_selected.jpg
Figure 3 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_8_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_8_4.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_7_5.jpg
(Cells in glomeruli Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_7_5.jpg
Figure 5 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_6_6.jpg
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53294/125386_A_6_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (RH-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132703-APCS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132703-APCS
Specifications
- Host Species
- Human
- Derivation
- Mouse
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Systemic amyloidosis
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- ≤1 year at -20°C.
Target
- Alternative Names
- APCS; amyloid P component, serum; SAP; PTX2; HEL-S-92n; serum amyloid P-component; pentaxin-related; 9.5S alpha-1-glycoprotein; epididymis secretory sperm binding protein Li 92n
- Gene ID
- 325
- UniProt ID
- P02743
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2232z | Mouse Anti-APCS Recombinant Antibody (clone 38A6) | WB, ELISA, FC, ICC, IF, IHC, IP | Mouse IgG1 |
| MOB-1834MZ | Mouse Anti-APCS Recombinant Antibody (clone IZC392-06) | ELISA, WB, sELISA | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-022CQ | Mouse Anti-APCS Recombinant Antibody (clone CBL362) | Block | Mouse IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0200 | Hi-Affi™ Rabbit Anti-APCS Recombinant Antibody (clone DS200AB) | IHC-P, WB | Rabbit IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-019ML | Anti-Human APCS Recombinant Antibody (Dezamizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-019ML | Afuco™ Anti-APCS ADCC Recombinant Antibody (Dezamizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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