Anti-Human BDNF Recombinant Antibody (B20) (CAT#: TAB-1248CL)
This ia an antibody that competes for binding to human BDNF, and it can be used in treating pain, such as chronic pain, neuropathic pain and symptoms, conditions and diseases associated with such pain.
Specific Inquiry
Inhib
Figure 1 Cell based ERK phosphorylation assay in U20S TrkB/p75NTR cells.
The humanised anti-BDNF molecule, B30 demonstrated greater BDNF binding compared to R3BH1 and TrkB-Fc, as measured by inhibition of pERK activity in U20S TrkBp75NTR cells.
Inhib
Figure2 Improved BDNF binding of humanised B30 clone in cell based TrkB phosphorylation assay in U20S TrkB/p75NTR cells.
B30 clone inhibits BDNF mediated TrkB receptor phosphorylation in TrkBp75NTR U20S cells.
FuncS
Figure 4 In vivo electrophysiological recordings of spinal dorsal horn neurones in rats sustaining peripheral nerve injury.
Mechanical punctate (von Frey) responses were dose dependency attenuated by the anti-BDNF molecule, B30 (0.1 and 1 mgkg) and pregabalin.
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- B20
- Applications
- Inhib, FuncS
- Related Disease
- Chronic pain
Applications
- Application Notes
- This antibody has been reported for use in Inhibition, Functional Assay.
Target
- Alternative Names
- BDNF; Brain-derived neurotrophic factor; Abrineurin; ANON2; brain-derived neurotrophic factor; BULN2; MGC34632; neurotrophin
- Gene ID
- 627
- UniProt ID
- P23560
Related Resources
Cocaine Addiction
Alcoholism
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-107 | Recombinant Anti-human BDNF Antibody | ELISA, WB, Dot, FuncS | IgG |
| MRO-1686-CN | Rabbit Anti-BDNF Polyclonal Antibody (MRO-1686-CN) | WB, IF, IHC | Rabbit IgG |
| VS3-CJ800 | Mouse Anti-BDNF Recombinant Antibody (VS3-CJ800) | WB | Mouse IgG |
| VS3-CJ801 | Rabbit Anti-BDNF Recombinant Antibody (VS3-CJ801) | WB, ICC, IF, IHC | Rabbit IgG |
| VS3-XY120 | Mouse Anti-BDNF Recombinant Antibody (clone 3D9C5) | ELISA, WB, ICC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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