Anti-Human BDNF Recombinant Antibody (B18) (CAT#: TAB-1249CL)
This ia an antibody that competes for binding to human BDNF, and it can be used in treating pain, such as chronic pain, neuropathic pain and symptoms, conditions and diseases associated with such pain.
Specific Inquiry
Inhib
Figure 1 Cell based ERK phosphorylation assay in U20S TrkB/p75NTR cells.
The humanised anti-BDNF molecule, B30 demonstrated greater BDNF binding compared to R3BH1 and TrkB-Fc, as measured by inhibition of pERK activity in U20S TrkBp75NTR cells.
Inhib
Figure2 Improved BDNF binding of humanised B30 clone in cell based TrkB phosphorylation assay in U20S TrkB/p75NTR cells.
B30 clone inhibits BDNF mediated TrkB receptor phosphorylation in TrkBp75NTR U20S cells.
FuncS
Figure 4 In vivo electrophysiological recordings of spinal dorsal horn neurones in rats sustaining peripheral nerve injury.
Mechanical punctate (von Frey) responses were dose dependency attenuated by the anti-BDNF molecule, B30 (0.1 and 1 mgkg) and pregabalin.
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- B18
- Applications
- FuncS
- Related Disease
- Chronic pain
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay.
Target
- Alternative Names
- BDNF; Brain-derived neurotrophic factor; Abrineurin; ANON2; brain-derived neurotrophic factor; BULN2; MGC34632; neurotrophin
- Gene ID
- 627
- UniProt ID
- P23560
Related Resources
Cocaine Addiction
Alcoholism
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-107-F(E) | Recombinant Anti-human BDNF Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| MHH-107-F(E) | Recombinant Human Anti-human BDNF Antibody Fab Fragment | ELISA, WB, Neut, FuncS | Fab |
| HPAB-0351-FY-F(E) | Human Anti-BDNF Recombinant Antibody (clone R3BH1); Fab Fragment | Block | Chimeric (chicken/human) Fab, λ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-107-S(P) | Recombinant Anti-human BDNF Antibody scFv Fragment | FC, RIA, Biosensors, FuncS | scFv |
| MHH-107-S(P) | Recombinant Human Anti-human BDNF Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| HPAB-0351-FY-S(P) | Chicken Anti-BDNF Recombinant Antibody (clone R3BH1); scFv Fragment | Block | Chicken scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-107 | Recombinant Human Anti-human BDNF Antibody | ELISA, WB, FuncS | IgG |
| MOB-0467MZ | Mouse Anti-BDNF Recombinant Antibody (clone 46039.22) | ELISA, IHC-P, WB | Mouse IgG1 |
| MRO-0166-CN | Rabbit Anti-BDNF Recombinant Antibody (clone CBACN-065) | WB, IHC, IF | Rabbit IgG |
| MRO-1686-CN | Rabbit Anti-BDNF Polyclonal Antibody (MRO-1686-CN) | WB, IF, IHC | Rabbit IgG |
| HPAB-0351-FY | Human Anti-BDNF Recombinant Antibody (clone R3BH1) | ELISA, Inhib, FuncS, Neut | Chimeric (chicken/human) lgG1, λ |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1247CL | Anti-Human BDNF Recombinant Antibody (B30) | Inhib, FuncS | Humanized antibody |
| TAB-1248CL | Anti-Human BDNF Recombinant Antibody (B20) | Inhib, FuncS | Humanized antibody |
| TAB-1247CL-S(P) | Anti-Human BDNF Recombinant Antibody scFv Fragment (B30) | Inhib, FuncS | Humanized antibody |
| TAB-1248CL-S(P) | Anti-Human BDNF Recombinant Antibody scFv Fragment (B20) | ELISA, Inhib | Humanized antibody |
| TAB-1249CL-S(P) | Anti-Human BDNF Recombinant Antibody scFv Fragment (B18) | ELISA, Inhib | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0825MZ | Chicken Anti-BDNF Polyclonal IgY | ELISA | Chicken antibody |
| BRD-1149MZ | Chicken Anti-Human BDNF Polyclonal IgY | ELISA | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-044CQ | Mouse Anti-BDNF Recombinant Antibody (clone CBL263) | ELISA, WB, Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0351 | Hi-Affi™ Rabbit Anti-BDNF Recombinant Antibody (clone DS351AB) | WB, IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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