Anti-Human BDNF Recombinant Antibody (B18)
CAT#: TAB-1249CL
This ia an antibody that competes for binding to human BDNF, and it can be used in treating pain, such as chronic pain, neuropathic pain and symptoms, conditions and diseases associated with such pain.
Published Data
Gene Expression
Inhib
Figure 1 Cell based ERK phosphorylation assay in U20S TrkB/p75NTR cells.
The humanised anti-BDNF molecule, B30 demonstrated greater BDNF binding compared to R3BH1 and TrkB-Fc, as measured by inhibition of pERK activity in U20S TrkBp75NTR cells.
Inhib
Figure2 Improved BDNF binding of humanised B30 clone in cell based TrkB phosphorylation assay in U20S TrkB/p75NTR cells.
B30 clone inhibits BDNF mediated TrkB receptor phosphorylation in TrkBp75NTR U20S cells.
FuncS
Figure 4 In vivo electrophysiological recordings of spinal dorsal horn neurones in rats sustaining peripheral nerve injury.
Mechanical punctate (von Frey) responses were dose dependency attenuated by the anti-BDNF molecule, B30 (0.1 and 1 mgkg) and pregabalin.
❮
❯
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31440/1056_B9_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9564/162501_B_7_5.jpg
Normal Tissue
Figure 3 Cerebellum
GLUC cells - cytoplasm/membrane
Staining: Medium
Intensity: Moderate
Granular cells - cytoplasm/membrane
Staining: Medium
Intensity: Moderate
Molecular layer cells - cytoplasm/membrane
Staining: Medium
Intensity: Moderate
Molecular layer cells - nucleus
Staining: Medium
Intensity: Moderate
Processes in molecular layer
Staining: Medium
Intensity: Moderate
Synaptic glomeruli - core
Staining: Medium
Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9564/162501_B_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HBF TERT88, U-138 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000176697-BDNF
❮
❯
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- B18
- Applications
- FuncS
- Related Disease
- Chronic pain
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for TAB-1249CL. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Cocaine Addiction
Alcoholism
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone B18"
- CAT
- Product Name
See other products for "BDNF"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-107-F(E) | Recombinant Anti-human BDNF Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| MHH-107-F(E) | Recombinant Human Anti-human BDNF Antibody Fab Fragment | ELISA, WB, Neut, FuncS | Fab |
| HPAB-0351-FY-F(E) | Human Anti-BDNF Recombinant Antibody (clone R3BH1); Fab Fragment | Block | Chimeric (chicken/human) Fab, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-107-S(P) | Recombinant Anti-human BDNF Antibody scFv Fragment | FC, RIA, Biosensors, FuncS | scFv |
| MHH-107-S(P) | Recombinant Human Anti-human BDNF Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| HPAB-0351-FY-S(P) | Chicken Anti-BDNF Recombinant Antibody (clone R3BH1); scFv Fragment | Block | Chicken scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-107 | Recombinant Human Anti-human BDNF Antibody | ELISA, WB, FuncS | IgG |
| MOB-0467MZ | Mouse Anti-BDNF Recombinant Antibody (clone 46039.22) | ELISA, IHC-P, WB | Mouse IgG1 |
| VS3-CJ800 | Mouse Anti-BDNF Recombinant Antibody (VS3-CJ800) | WB | Mouse IgG |
| VS3-CJ801 | Rabbit Anti-BDNF Recombinant Antibody (VS3-CJ801) | WB, ICC, IF, IHC | Rabbit IgG |
| VS3-XY120 | Mouse Anti-BDNF Recombinant Antibody (clone 3D9C5) | ELISA, WB, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1247CL | Anti-Human BDNF Recombinant Antibody (B30) | Inhib, FuncS | Humanized antibody |
| TAB-1248CL | Anti-Human BDNF Recombinant Antibody (B20) | Inhib, FuncS | Humanized antibody |
| TAB-1247CL-F(E) | Anti-Human BDNF Recombinant Antibody Fab Fragment (B30) | Inhib, FuncS | Humanized antibody |
| TAB-1248CL-F(E) | Anti-Human BDNF Recombinant Antibody Fab Fragment (B20) | ELISA, Inhib | Humanized antibody |
| TAB-1249CL-F(E) | Anti-Human BDNF Recombinant Antibody Fab Fragment (B18) | ELISA, Inhib | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0825MZ | Chicken Anti-BDNF Polyclonal IgY | ELISA | Chicken antibody |
| BRD-1149MZ | Chicken Anti-Human BDNF Polyclonal IgY | ELISA | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-044CQ | Mouse Anti-BDNF Recombinant Antibody (clone CBL263) | ELISA, WB, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0351 | Hi-Affi™ Rabbit Anti-BDNF Recombinant Antibody (clone DS351AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC576 | Recombinant Anti-BDNF Vesicular Antibody, EV Displayed (VS-0425-YC576) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY753 | Anti-BDNF Immunohistochemistry Kit | IHC | |
| VS-0525-XY754 | Anti-Mouse BDNF Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, Inhib, ICC, WB
Application: ELISA, FC, WB, Block
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, IHC, FC, IP, IF, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
