This anti-C1s monoclonal antibody is useful for the diagnosis and treatment of disorders associated with an increased activation of the classical complement pathway, in particular autoimmune disorders and neurodegenerative diseases, including neurodegenerative diseases with synapse loss, such as Alzheimer's Disease.
Figure 1 The results of an ELISA screen for antibodies specifically binding human Cls or human Cls proenzyme.
The binding assays were conducted either in the absence of an anti-Cls antibody ("media") or in the presence of one of six anti-Cls antibodies (1B4, 3F8, 3G3, 5A1, 5C12, or 7C4). Left columns show binding signals for anti-Cls antibody binding to the Cls protein; middle columns show binding signals for anti-Cls antibody binding to the Cls proenzyme; right columns show binding signals for anti-Cls antibody binding to the human transferrin (HT) negative control protein.
Figure 2 The Cls neutralizing activities of anti-Cls antibodies in a C IF hemolytic assay.
FIG. A illustrates the results of assays conducted with six anti-Cls antibodies (1B4, 3F8, 3G3, 5A1, 5C12, or 7C4) in a single-dose format. FIG. B shows the results of C1F hemolytic assays conducted with two anti-Cls antibodies (5A1 and 5C12) in a dose-response format.
Figure 3 The Cls neutralizing activities of anti-Cls antibodies in a C4 cleavage assay.
The upper panel illustrates the activity of eight anti-Cls antibodies (M241, 3F8, 3A1, 3A2, 2A1, 5C12, 6HK, and 8HK) regarding the inhibition of C4 cleavage at a single concentration. The lower panel illustrates the neutralizing activities of two anti-Cls antibodies (5A1 and 5C12) in a dose-response format.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-290-sdAb | Recombinant Anti-Human C1s VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1188z | Mouse Anti-C1S Recombinant Antibody (clone 43C8) | WB, IP, IHC, FuncS | Mouse IgG2a |
MOB-0274CT | Mouse Anti-C1S Recombinant Antibody (clone 50) | ELISA | Mouse IgG2a |
HPAB-1493LY | Human Anti-C1S Recombinant Antibody (HPAB-1493LY) | ELISA | Humanized IgG |
HPAB-N0028-YC | Human Anti-C1s Recombinant Antibody (HPAB-N0028-YC) | ELISA | Humanized IgG |
MOR-0023-FY | Mouse Anti-C1S Recombinant Antibody (clone M81) | FC, FuncS, IA, IP, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0087CL | Mouse Anti-C1S Recombinant Antibody (TAB-0087CL) | ELISA, CMDC, Stim, Hemolysis, Inhib | Mouse IgG |
TAB-1327CL | Anti-Human C1S Recombinant Antibody (5C12) | ELISA, Neut | |
TAB-0087CL-S(P) | Mouse Anti-C1S Recombinant Antibody; scFv Fragment (TAB-0087CL-S(P)) | ELISA, Stim, Inhib | Mouse scFv |
TAB-1326CL-S(P) | Anti-Human C1S Recombinant Antibody scFv Fragment (5A1) | ELISA, FuncS | |
TAB-0087CL-F(E) | Mouse Anti-C1S Recombinant Antibody; Fab Fragment (TAB-0087CL-F(E)) | ELISA, Stim, Inhib | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0088CL | Human Anti-C1S Recombinant Antibody (TAB-0088CL) | ELISA, CMDC, Stim, Hemolysis, Inhib | Humanized Antibody |
TAB-0088CL-S(P) | Human Anti-C1S Recombinant Antibody; scFv Fragment (TAB-0088CL-S(P)) | ELISA, Stim, Inhib | Humanized scFv |
TAB-0088CL-F(E) | Human Anti-C1S Recombinant Antibody; Fab Fragment (TAB-0088CL-F(E)) | ELISA, Stim, Inhib | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-078CQ | Mouse Anti-C1S Recombinant Antibody (clone M241) | WB, Neut, FC, IA, IHC, IHC-Fr, IHC-P | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0410 | Hi-Affi™ Rabbit Anti-C1S Recombinant Antibody (clone DS410AB) | WB | Rabbit IgG |
MOR-0411 | Hi-Affi™ Rabbit Anti-C1S Recombinant Antibody (clone DS411AB) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1493LY-S(P) | Human Anti-C1S Recombinant Antibody; scFv Fragment (HPAB-1493LY-S(P)) | ELISA | Human scFv |
HPAB-N0028-YC-S(P) | Human Anti-C1s Recombinant Antibody; scFv Fragment (HPAB-N0028-YC-S(P)) | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1493LY-F(E) | Human Anti-C1S Recombinant Antibody; Fab Fragment (HPAB-1493LY-F(E)) | ELISA | Humanized Fab |
HPAB-N0028-YC-F(E) | Human Anti-C1s Recombinant Antibody; Fab Fragment (HPAB-N0028-YC-F(E)) | ELISA | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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