Anti-Human C1S Recombinant Antibody (5A1) (CAT#: TAB-1326CL)
This anti-C1s monoclonal antibody is useful for the diagnosis and treatment of disorders associated with an increased activation of the classical complement pathway, in particular autoimmune disorders and neurodegenerative diseases, including neurodegenerative diseases with synapse loss, such as Alzheimer's Disease.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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ELISA
Figure 1 The results of an ELISA screen for antibodies specifically binding human Cls or human Cls proenzyme.
The binding assays were conducted either in the absence of an anti-Cls antibody ("media") or in the presence of one of six anti-Cls antibodies (1B4, 3F8, 3G3, 5A1, 5C12, or 7C4). Left columns show binding signals for anti-Cls antibody binding to the Cls protein; middle columns show binding signals for anti-Cls antibody binding to the Cls proenzyme; right columns show binding signals for anti-Cls antibody binding to the human transferrin (HT) negative control protein.
Neut
Figure 2 The Cls neutralizing activities of anti-Cls antibodies in a C IF hemolytic assay.
FIG. A illustrates the results of assays conducted with six anti-Cls antibodies (1B4, 3F8, 3G3, 5A1, 5C12, or 7C4) in a single-dose format. FIG. B shows the results of C1F hemolytic assays conducted with two anti-Cls antibodies (5A1 and 5C12) in a dose-response format.
Neut
Figure 3 The Cls neutralizing activities of anti-Cls antibodies in a C4 cleavage assay.
The upper panel illustrates the activity of eight anti-Cls antibodies (M241, 3F8, 3A1, 3A2, 2A1, 5C12, 6HK, and 8HK) regarding the inhibition of C4 cleavage at a single concentration. The lower panel illustrates the neutralizing activities of two anti-Cls antibodies (5A1 and 5C12) in a dose-response format.
Specifications
- Immunogen
- Human C1s enzyme purified from human plasma
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 5A1
- Applications
- ELISA, Neut
- Related Disease
- Autoimmune disorders and neurodegenerative diseases, including neurodegenerative diseases with synapse loss, such as Alzheimer's Disease
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay and Neutralization.
Target
- Alternative Names
- C1S; complement component 1, s subcomponent; complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s
- Gene ID
- 716
- UniProt ID
- P09871
Related Resources
Systemic Lupus Erythematosus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-290-sdAb | Recombinant Anti-Human C1s VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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