Mouse Anti-C1S (clone 5C12) scFv-Fc Chimera (CAT#: VS-0425-FY69)
This fusion protein targets C1S, a key serine protease in the complement system. It holds potential for use in treating autoimmune or inflammatory disorders by modulating the complement pathway.
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/1446_A3_2_selected.jpg
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/1446_A3_2_selected.jpg
Figure 2 IHC staining of human prostate
(Immunohistochemical staining of human prostate shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/ihc_selected.jpg
(Immunohistochemical staining of human prostate shows distinct positivity in plasma.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/ihc_selected.jpg
Figure 3 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/1184_H1_4_red_green.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/1184_H1_4_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & Cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/151_A11_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & Cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/151_A11_1_red_green.jpg
Specifications
- Immunogen
- Human Cls enzyme purified from human plasma.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- The 5C12 clone produces an antibody that specifically binds to both the mature Cls protease and the Cls proenzyme.
- Species Reactivity
- Human
- Clone
- 5C12
- Applications
- ELISA, Neutralization
- Related Disease
- Ehlers-Danlos Syndrome, Periodontal Type, 2 and Complement Component C1s Deficiency
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Neutralization: 165 ng/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- EDSPD2
- Gene ID
- 716
- UniProt ID
- P09871
- Long Name
- complement C1s
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Cytosol, Nucleoplasm
- Post Translation Modifications
- The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Glycosylation at Asn174 and Asn406
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect C1S_HUMAN (1144)
Glycosylation from GlyGen 3 sites, 7 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054229092.1; NP_001333779.1; NP_001725.1; NP_958850.1
- Function
- C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.
C1r activates C1s so that it can, in turn, activate C2 and C4.
Cleaves also IGFBP5 and thereby inhibits the trophic effects of IGF1.
Related Resources
Systemic Lupus Erythematosus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-290-sdAb | Recombinant Anti-Human C1s VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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