Mouse Anti-C1S (clone 5C12) scFv-Fc Chimera
CAT#: VS-0425-FY69
This fusion protein targets C1S, a key serine protease in the complement system. It holds potential for use in treating autoimmune or inflammatory disorders by modulating the complement pathway.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/1446_A3_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human prostate
Immunohistochemical staining of human prostate shows distinct positivity in plasma.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/1184_H1_4_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18852/151_A11_1_red_green.jpg
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Specifications
- Immunogen
- Human Cls enzyme purified from human plasma.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- The 5C12 clone produces an antibody that specifically binds to both the mature Cls protease and the Cls proenzyme.
- Species Reactivity
- Human
- Clone
- 5C12
- Applications
- ELISA, Neutralization
- Related Disease
- Ehlers-Danlos Syndrome, Periodontal Type, 2 and Complement Component C1s Deficiency
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Neutralization: 165 ng/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- EDSPD2
- Gene ID
- 716
- UniProt ID
- P09871
- Long Name
- complement C1s
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Cytosol, Nucleoplasm
- Post Translation Modifications
- The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Glycosylation at Asn174 and Asn406
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect C1S_HUMAN (1144)
Glycosylation from GlyGen 3 sites, 7 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054229092.1; NP_001333779.1; NP_001725.1; NP_958850.1
- Function
- C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.
C1r activates C1s so that it can, in turn, activate C2 and C4.
Cleaves also IGFBP5 and thereby inhibits the trophic effects of IGF1.
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Related Diseases
Systemic Lupus Erythematosus
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 5C12"
- CAT
- Product Name
See other products for "C1s"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-290-sdAb | Recombinant Anti-Human C1s VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1188z | Mouse Anti-C1S Recombinant Antibody (clone 43C8) | WB, IP, IHC, FuncS | Mouse IgG2a |
| MOB-0274CT | Mouse Anti-C1S Recombinant Antibody (clone 50) | ELISA | Mouse IgG2a |
| HPAB-1493LY | Human Anti-C1S Recombinant Antibody (HPAB-1493LY) | ELISA | Humanized IgG |
| HPAB-N0028-YC | Human Anti-C1s Recombinant Antibody (HPAB-N0028-YC) | ELISA | Humanized IgG |
| MOR-0023-FY | Mouse Anti-C1S Recombinant Antibody (clone M81) | FC, FuncS, IA, IP, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0087CL | Mouse Anti-C1S Recombinant Antibody (TAB-0087CL) | ELISA, CMDC, Stim, Hemolysis, Inhib | Mouse IgG |
| TAB-1326CL | Anti-Human C1S Recombinant Antibody (5A1) | ELISA, Neut | |
| TAB-0087CL-S(P) | Mouse Anti-C1S Recombinant Antibody; scFv Fragment (TAB-0087CL-S(P)) | ELISA, Stim, Inhib | Mouse scFv |
| TAB-1326CL-S(P) | Anti-Human C1S Recombinant Antibody scFv Fragment (5A1) | ELISA, FuncS | |
| TAB-1327CL-S(P) | Anti-Human C1S Recombinant Antibody scFv Fragment (5C12) | ELISA, FuncS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0088CL | Human Anti-C1S Recombinant Antibody (TAB-0088CL) | ELISA, CMDC, Stim, Hemolysis, Inhib | Humanized Antibody |
| TAB-0088CL-S(P) | Human Anti-C1S Recombinant Antibody; scFv Fragment (TAB-0088CL-S(P)) | ELISA, Stim, Inhib | Humanized scFv |
| TAB-0088CL-F(E) | Human Anti-C1S Recombinant Antibody; Fab Fragment (TAB-0088CL-F(E)) | ELISA, Stim, Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-078CQ | Mouse Anti-C1S Recombinant Antibody (clone M241) | WB, Neut, FC, IA, IHC, IHC-Fr, IHC-P | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0410 | Hi-Affi™ Rabbit Anti-C1S Recombinant Antibody (clone DS410AB) | WB | Rabbit IgG |
| MOR-0411 | Hi-Affi™ Rabbit Anti-C1S Recombinant Antibody (clone DS411AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1493LY-S(P) | Human Anti-C1S Recombinant Antibody; scFv Fragment (HPAB-1493LY-S(P)) | ELISA | Human scFv |
| HPAB-N0028-YC-S(P) | Human Anti-C1s Recombinant Antibody; scFv Fragment (HPAB-N0028-YC-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1493LY-F(E) | Human Anti-C1S Recombinant Antibody; Fab Fragment (HPAB-1493LY-F(E)) | ELISA | Humanized Fab |
| HPAB-N0028-YC-F(E) | Human Anti-C1s Recombinant Antibody; Fab Fragment (HPAB-N0028-YC-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY281 | Anti-C1S Immunohistochemistry Kit | IHC | |
| VS-0525-XY878 | Anti-Mouse C1S Immunohistochemistry Kit | IHC | |
| VS-0525-XY877 | Anti-Human C1S Immunohistochemistry Kit | IHC |
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