Anti-Human CDCP1 Recombinant Antibody (ch25A11)
CAT#: TAB-404LC
This product is a recombinant mouse antibody that recognizes CDCP1. The antibody is internalized after binding and can kill PC-3 cells during in vitro transplantation and invasion in vitro. antibody treatment at 0.8 μM resulted in a 78% inhibition of PC-3 cell migration compared to the PBS/complete medium control.
Published Data
Gene Expression
FC
Figure 1 FACS profile of chimeric 25Al 1 IgG on PC-3, DuI 45 cell lines.
LN met is lymph node metastasis. GFI is the geometric mean of fluorescence intensity.
IHC
Figure 2 IHC staining of 25Al 1 on 1 : PC-3 cells, secondary alone (negative control), 2: PC-3 cells (positive control), 3: Patient 2, benign glands, 4: Patient 2, malignant glands, 5: Patient 5, benign glands, 6: Patient 5, malignant glands.
FuncS
Figure 3 Summary of cell migration and invasion assays. PC-3 cells were treated with titrations of ch25Al 1 or CUBl, or 2.5 μM of PP2 and tested in Boyden chambers for inhibition of cell migration and invasion.
FuncS
Figure 4 shows the internalization assay using anti-CDCPl antibodies with appropriate saporin secondary conjugates, or with ch25Al 1-Sap direct conjugate.
FuncS
Figure 5 Effect of ch25Al 1 -saporin direct conjugate on PC-3 tumor growth.
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Normal Tissue
Figure 1 High expression in esophagus
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10978/28098_B_5_1_val_selected.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10979/28106_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10979/28106_A_5_6.jpg
Normal Tissue
Figure 4 Prostate
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10979/28106_A_3_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10979/28106_A_7_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10979/28106_A_7_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163814-CDCP1
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Specifications
- Host Species
- Human
- Derivation
- Chimeric (Mouse/human)
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Clone
- ch25A11
- Applications
- FC, FuncS, IHC
- Related Disease
- Prostate cancer
Applications
- Application Notes
- This antibody has been reported for use in Flow Cytometry, Functional Assay, Immunohistochemistry.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone ch25A11"
- CAT
- Product Name
See other products for "CDCP1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-149CL | Human Anti-CDCP1 Recombinant Antibody (TAB-149CL) | FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-403LC | Anti-Human CDCP1 Recombinant Antibody (25A11) | FC, FuncS, IHC | |
| TAB-403LC-S(P) | Anti-Human CDCP1 Recombinant Antibody scFv Fragment (25A11) | FC, IHC, ELISA | |
| TAB-403LC-F(E) | Anti-Human CDCP1 Recombinant Antibody Fab Fragment (25A11) | FC, IHC, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-404LC-S(P) | Anti-Human CDCP1 Recombinant Antibody scFv Fragment (ch25A11) | FC, IHC, ELISA | Chimeric antibody (mouse/human) |
| TAB-404LC-F(E) | Anti-Human CDCP1 Recombinant Antibody Fab Fragment (ch25A11) | FC, IHC, ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4074 | Hi-Affi™ Rabbit Anti-CDCP1 Recombinant Antibody (clone SI141DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1060-FY | Human Anti-CDCP1 Recombinant Antibody (clone 65E8) | ELISA, FC | Human IgG |
| HPAB-1061-FY | Human Anti-CDCP1 Recombinant Antibody (clone 79C12) | ELISA, FC | Human IgG |
| HPAB-1062-FY | Human Anti-CDCP1 Recombinant Antibody (clone 23E9) | ELISA, FC | Human IgG |
| HPAB-1063-FY | Human Anti-CDCP1 Recombinant Antibody (clone 36C1) | ELISA, FC | Human IgG |
| HPAB-1064-FY | Human Anti-CDCP1 Recombinant Antibody (clone 84H7) | ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1063WJ-S(P) | Mouse Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1063WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-1064WJ-S(P) | Human Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1064WJ-S(P)) | ELISA | Humanized scFv |
| HPAB-1070WJ-S(P) | Mouse Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1070WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-1071WJ-S(P) | Mouse Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1071WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-1072WJ-S(P) | Mouse Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1072WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1063WJ-F(E) | Mouse Anti-CDCP1 Recombinant Antibody; Fab Fragment (HPAB-1063WJ-F(E)) | ELISA | Mouse Fab |
| HPAB-1064WJ-F(E) | Human Anti-CDCP1 Recombinant Antibody; Fab Fragment (HPAB-1064WJ-F(E)) | ELISA | Humanized Fab |
| HPAB-1070WJ-F(E) | Mouse Anti-CDCP1 Recombinant Antibody; Fab Fragment (HPAB-1070WJ-F(E)) | ELISA | Mouse Fab |
| HPAB-1071WJ-F(E) | Mouse Anti-CDCP1 Recombinant Antibody; Fab Fragment (HPAB-1071WJ-F(E)) | ELISA | Mouse Fab |
| HPAB-1072WJ-F(E) | Mouse Anti-CDCP1 Recombinant Antibody; Fab Fragment (HPAB-1072WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY82 | CytoStream™ Mouse Anti-CDCP1 Recombinant Antibody (clone CUB1) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC160 | Recombinant Anti-CDCP1 Vesicular Antibody, EV Displayed (VS-0425-YC160) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1277 | Anti-CDCP1 Immunohistochemistry Kit | IHC |
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