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    Recombinant Anti-human DLG4 Intrabody [Tat] (CAT#: IAB-B004(T))

    Recombinant anti-DLG4 intrabody in fusion with HIV Tat works within cells directed against endogenous neuronal protein DLG4, expressed in E. coli cells. The intrabody can report the localization and amount of endogenous synaptic proteins in living neurons and thus may be used to study changes in synaptic strength in vivo.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 High expression in cerebral cortex
    Figure 1 High expression in cerebral cortex

    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10122/24907_B_7_5_val_selected.jpg
    Figure 2 Low expression in liver
    Figure 2 Low expression in liver

    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10122/24907_A_8_4_val_selected.jpg
    Figure 3 IHC staining of human cerebral cortex
    Figure 3 IHC staining of human cerebral cortex
    (Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic and nuclear positivity in neuronal cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71006/170683_B_7_5_selected.jpg
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1999/5316_B_8_5.jpg
    Figure 5 Cerebellum
    Figure 5 Cerebellum
    (Bergmann glia - cytoplasm/membrane Staining: Not detected Intensity: Negative Bergmann glia - nucleus Staining: Not detected Intensity: Negative GLUC cells - cytoplasm/membrane Staining: Medium Intensity: Moderate GLUC cells - nucleus Staining: Not detected Intensity: Negative Granular cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Granular cells - nucleus Staining: Medium Intensity: Moderate Molecular layer - neuropil Staining: Not detected Intensity: Negative Molecular layer cells - cytoplasm/membrane Staining: High Intensity: Strong Molecular layer cells - nucleus Staining: Not detected Intensity: Negative Processes in granular layer Staining: Not detected Intensity: Negative Processes in molecular layer Staining: Not detected Intensity: Negative Processes in white matter Staining: Not detected Intensity: Negative Purkinje cells - cytoplasm/membrane Staining: Medium Intensity: Moderate Purkinje cells - dendrites Staining: Not detected Intensity: Negative Purkinje cells - nucleus Staining: Not detected Intensity: Negative Synaptic glomeruli - capsule Staining: Not detected Intensity: Negative Synaptic glomeruli - core Staining: Medium Intensity: Moderate White matter cells - cytoplasm/membrane Staining: Not detected Intensity: Negative White matter cells - nucleus Staining: Not detected Intensity: Negative)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1999/5316_B_8_8.jpg
    RNA Expression
    Figure 6 RNA cell line category: Cell line enhanced (HMC-1, hTERT-RPE1)
    Figure 6 RNA cell line category: Cell line enhanced (HMC-1, hTERT-RPE1)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132535-DLG4

    Specifications

    • Immunogen
    • human discs, large homolog 4 (Drosophila)
    • Host Species
    • human
    • Type
    • scFv-Tat
    • Cell Penetrating Peptide
    • TAT
      TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
    • Species Reactivity
    • human
    • Applications
    • Formats of immunological tests: Immunofluorescence; Flow Cytometry; Functional studies

    Product Property

    • Purity
    • >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
    • Storage
    • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

    Target

    • Alternative Names
    • DLG4; discs, large homolog 4 (Drosophila); PSD95; SAP90; SAP-90; disks large homolog 4; discs large homolog 4; Tax interaction protein 15; synapse-associated protein 90; postsynaptic density protein 95; post-synaptic density protein 95

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

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    Intrabody Products IgG Antibody Products Blocking Antibody Products Rabbit Monoclonal Antibody Products Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
    CAT Product Name Application Type
    IAB-B004(A) Recombinant Anti-human DLG4 Intrabody [(D-Arg)9] WB, Neut, FuncS scFv-(D-Arg)9
    IAB-B004(G) Recombinant Anti-human DLG4 Intrabody [+36 GFP] WB, ICC, Neut, FuncS scFv-(+36GFP)

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