Recombinant Anti-human DLG4 Intrabody [(D-Arg)9] (CAT#: IAB-B004(A))
Recombinant anti-DLG4 intrabody linked to (D-Arg)9 works within cells directed against endogenous neuronal protein DLG4, expressed in E. coli cells. The intrabody can report the localization and amount of endogenous synaptic proteins in living neurons and thus may be used to study changes in synaptic strength in vivo.
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Normal Tissue
RNA Expression
Figure 1 High expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10122/24907_B_7_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10122/24907_B_7_5_val_selected.jpg
Figure 2 Low expression in liver
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10122/24907_A_8_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10122/24907_A_8_4_val_selected.jpg
Figure 3 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic and nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71006/170683_B_7_5_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic and nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71006/170683_B_7_5_selected.jpg
Figure 4 Cerebral cortex
(Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1999/5316_B_8_5.jpg
(Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1999/5316_B_8_5.jpg
Figure 5 Cerebellum
(Bergmann glia - cytoplasm/membrane Staining: Not detected Intensity: Negative Bergmann glia - nucleus Staining: Not detected Intensity: Negative GLUC cells - cytoplasm/membrane Staining: Medium Intensity: Moderate GLUC cells - nucleus Staining: Not detected Intensity: Negative Granular cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Granular cells - nucleus Staining: Medium Intensity: Moderate Molecular layer - neuropil Staining: Not detected Intensity: Negative Molecular layer cells - cytoplasm/membrane Staining: High Intensity: Strong Molecular layer cells - nucleus Staining: Not detected Intensity: Negative Processes in granular layer Staining: Not detected Intensity: Negative Processes in molecular layer Staining: Not detected Intensity: Negative Processes in white matter Staining: Not detected Intensity: Negative Purkinje cells - cytoplasm/membrane Staining: Medium Intensity: Moderate Purkinje cells - dendrites Staining: Not detected Intensity: Negative Purkinje cells - nucleus Staining: Not detected Intensity: Negative Synaptic glomeruli - capsule Staining: Not detected Intensity: Negative Synaptic glomeruli - core Staining: Medium Intensity: Moderate White matter cells - cytoplasm/membrane Staining: Not detected Intensity: Negative White matter cells - nucleus Staining: Not detected Intensity: Negative)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1999/5316_B_8_8.jpg
(Bergmann glia - cytoplasm/membrane Staining: Not detected Intensity: Negative Bergmann glia - nucleus Staining: Not detected Intensity: Negative GLUC cells - cytoplasm/membrane Staining: Medium Intensity: Moderate GLUC cells - nucleus Staining: Not detected Intensity: Negative Granular cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Granular cells - nucleus Staining: Medium Intensity: Moderate Molecular layer - neuropil Staining: Not detected Intensity: Negative Molecular layer cells - cytoplasm/membrane Staining: High Intensity: Strong Molecular layer cells - nucleus Staining: Not detected Intensity: Negative Processes in granular layer Staining: Not detected Intensity: Negative Processes in molecular layer Staining: Not detected Intensity: Negative Processes in white matter Staining: Not detected Intensity: Negative Purkinje cells - cytoplasm/membrane Staining: Medium Intensity: Moderate Purkinje cells - dendrites Staining: Not detected Intensity: Negative Purkinje cells - nucleus Staining: Not detected Intensity: Negative Synaptic glomeruli - capsule Staining: Not detected Intensity: Negative Synaptic glomeruli - core Staining: Medium Intensity: Moderate White matter cells - cytoplasm/membrane Staining: Not detected Intensity: Negative White matter cells - nucleus Staining: Not detected Intensity: Negative)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1999/5316_B_8_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (HMC-1, hTERT-RPE1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132535-DLG4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132535-DLG4
Specifications
- Immunogen
- human discs, large homolog 4 (Drosophila)
- Host Species
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Can be useful in applications such as: Western blot; Neutralization; Functional studies
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- DLG4; discs, large homolog 4 (Drosophila); PSD95; SAP90; SAP-90; disks large homolog 4; discs large homolog 4; Tax interaction protein 15; synapse-associated protein 90; postsynaptic density protein 95; post-synaptic density protein 95
- Gene ID
- 1742
- UniProt ID
- P78352
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B004(G) | Recombinant Anti-human DLG4 Intrabody [+36 GFP] | WB, ICC, Neut, FuncS | scFv-(+36GFP) |
| IAB-B004(T) | Recombinant Anti-human DLG4 Intrabody [Tat] | IF, FC, FuncS | scFv-Tat |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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