Anti-DLG4 Intrabody [(D-Arg)9] (IAB-B004(A))
Recombinant anti-DLG4 intrabody linked to (D-Arg)9 works within cells directed against endogenous neuronal protein DLG4, expressed in E. coli cells. The intrabody can report the localization and amount of endogenous synaptic proteins in living neurons and thus may be used to study changes in synaptic strength in vivo.
Specifications
- Immunogen
- human discs, large homolog 4 (Drosophila)
- Host
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Can be useful in applications such as: Western blot; Neutralization; Functional studies
Target
- Alternative Names
- DLG4; discs, large homolog 4 (Drosophila); PSD95; SAP90; SAP-90; disks large homolog 4; discs large homolog 4; Tax interaction protein 15
- Entrez Gene ID
- 1742
- UniProt ID
- P78352
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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