Anti-DLL3 Antibody Prodrug, Protease Activated (VS-1025-YC145)
CAT#: VS-1025-YC145
The Anti-DLL3 Antibody Prodrug, Protease Activated (VS-1025-YC145) is an antibody prodrug comprised of a recombinant mouse antibody targeting human DLL3, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to DLL3 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to DLL3 effectively. DLL3 (Delta-Like 3) is a ligand for the NOTCH pathway whose expression is highly restricted to the nervous system but is aberrantly expressed in high-grade neuroendocrine tumors, particularly small-cell lung cancer (SCLC). This makes it a highly specific and promising target for antibody-drug conjugates (ADCs) that spare normal tissue.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/24559/1931_D10_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56533/1219_G4_3_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000090932-DLL3
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human DLL3
- Target
- DLL3
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- Alternative Names
- Delta Like Canonical Notch Ligand 3; Delta3; Delta-Like 3 (Drosophila); Delta-Like Protein 3; Delta-Like 3; SCDO1
- Gene ID
- 10683
- UniProt ID
- Q9NYJ7
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "DLL3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-212MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-212MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-213MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-213MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-214MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-214MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-215MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-215MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-212MZ-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (TAB-212MZ-S(P)) | FC, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-043CQ | Goat Anti-Human DLL3 Polyclonal Antibody | WB, FC | Goat IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2093LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2093LY-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2094LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2094LY-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2095LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2095LY-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2096LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2096LY-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2097LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2097LY-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2093LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2093LY) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2094LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2094LY) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2095LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2095LY) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2096LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2096LY) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2093LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2093LY-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2094LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2094LY-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2095LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2095LY-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2096LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2096LY-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2097LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2097LY-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY7 | Human Anti-DLL3 scFv-Fc Chimera (VS-0325-FY7) | ADCC, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC208 | Recombinant Anti-DLL3 Vesicular Antibody, EV Displayed (VS-0425-YC208) | Cyt, ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2017 | Anti-DLL3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC48 | Recombinant Anti-DLL3 (DSL domain x EGF-like domain) Biparatopic Antibody, Tandem scFv | Cyt, ELISA, FC, Inhib | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC101 | SmartAb™ Recombinant Anti-DLL3 pH-dependent Antibody (VS-0825-YC101) | ELISA | Human IgG |
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