Recombinant Anti-DLL3 Vesicular Antibody, EV Displayed (VS-0425-YC208)
CAT#: VS-0425-YC208
The Recombinant Anti-DLL3 Vesicular Antibody, EV Displayed (VS-0425-YC208) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to DLL3-expressed cells or tissues. The DLL3 is a delta protein ligand functioning as a Notch ligand. Mutations cause spondylocostal dysostosis 1, with identified transcript variants.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/24559/1931_D10_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56533/1219_G4_3_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000090932-DLL3
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Recombinant Antibody
- Application
- Cyt, ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- DLL3
- Host Animal
- Mouse
- Antibody Isotype
- IgG2a
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Delta like canonical Notch ligand 3
- Biological Process
- Differentiation, Notch signaling pathway
- Molecular Function
- Developmental protein
- Cellular Localization
- Nucleoplasm, Golgi apparatus, Plasma membrane
- Introduction
- This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
- Alternative Names
- SCDO1
- Gene ID
- 10683
- UniProt ID
- Q9NYJ7
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Datasheet
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COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-212MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-212MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| TAB-212MZ-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (TAB-212MZ-S(P)) | FC, ELISA | Mouse scFv |
| TAB-213MZ-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (TAB-213MZ-S(P)) | FC, ELISA | Mouse scFv |
| TAB-214MZ-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (TAB-214MZ-S(P)) | FC, ELISA | Mouse scFv |
| TAB-215MZ-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (TAB-215MZ-S(P)) | FC, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2100LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2100LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2101LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2101LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2102LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2102LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2103LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2103LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2104LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2104LY-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2112LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2112LY) | ELISA, FC | Mouse IgG |
| HPAB-2113LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2113LY) | ELISA, FC | Mouse IgG |
| HPAB-2114LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2114LY) | ELISA, FC | Mouse IgG |
| HPAB-2115LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2115LY) | ELISA, FC | Mouse IgG |
| HPAB-2116LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2116LY) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2112LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2112LY-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2113LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2113LY-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2114LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2114LY-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2115LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2115LY-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2116LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2116LY-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY7 | Human Anti-DLL3 scFv-Fc Chimera (VS-0325-FY7) | ADCC, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2017 | Anti-DLL3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC48 | Recombinant Anti-DLL3 (DSL domain x EGF-like domain) Biparatopic Antibody, Tandem scFv | Cyt, ELISA, FC, Inhib | Tandem scFv |
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