Human Anti-DLL3 scFv-Fc Chimera (VS-0325-FY7)
CAT#: VS-0325-FY7
Anti-DLL3 scFv-Fc is an antibody targeting Delta-like protein 3 (DLL3), capable of binding to DLL3 on the surface of small cell lung cancer (SCLC) cells. Its potential function lies in being part of immunotherapy for the treatment of SCLC, thereby helping to enhance the immune system's recognition and clearance of these tumor cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/24559/1931_D10_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56533/1219_G4_3_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000090932-DLL3
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human DLL3
- Species Reactivity
- Human
- Applications
- ADCC, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Delta Like Canonical Notch Ligand 3; Drosophila Delta Homolog 3; Delta3; Delta (Drosophila)-Like 3; Delta-Like 3 (Drosophila); Delta-Like Protein 3; Delta-Like 3; SCDO1
- Gene ID
- 10683
- UniProt ID
- Q9NYJ7
- Long Name
- Delta Like Canonical Notch Ligand 3
- Cellular Localization
- Membrane
- Post Translation Modifications
- Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_058637.1; NP_982353.1
- Function
- Inhibits primary neurogenesis.
May be required to divert neurons along a specific differentiation pathway.
Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "DLL3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-212MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-212MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| TAB-213MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-213MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| TAB-214MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-214MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| TAB-215MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-215MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| TAB-212MZ-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (TAB-212MZ-F(E)) | FC, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-043CQ | Goat Anti-Human DLL3 Polyclonal Antibody | WB, FC | Goat IgG |
| HPAB-2112LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2112LY) | ELISA, FC | Mouse IgG |
| HPAB-2113LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2113LY) | ELISA, FC | Mouse IgG |
| HPAB-2114LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2114LY) | ELISA, FC | Mouse IgG |
| HPAB-2115LY | Mouse Anti-DLL3 Recombinant Antibody (HPAB-2115LY) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2100LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2100LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2101LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2101LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2102LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2102LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2103LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2103LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2104LY-F(E) | Mouse Anti-DLL3 Recombinant Antibody; Fab Fragment (HPAB-2104LY-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2112LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2112LY-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2113LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2113LY-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2114LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2114LY-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2115LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2115LY-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2116LY-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (HPAB-2116LY-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC208 | Recombinant Anti-DLL3 Vesicular Antibody, EV Displayed (VS-0425-YC208) | Cyt, ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2017 | Anti-DLL3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC48 | Recombinant Anti-DLL3 (DSL domain x EGF-like domain) Biparatopic Antibody, Tandem scFv | Cyt, ELISA, FC, Inhib | Tandem scFv |
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