Human Anti-DLL3 scFv-Fc Chimera (VS-0325-FY7) (CAT#: VS-0325-FY7)
Anti-DLL3 scFv-Fc is an antibody targeting Delta-like protein 3 (DLL3), capable of binding to DLL3 on the surface of small cell lung cancer (SCLC) cells. Its potential function lies in being part of immunotherapy for the treatment of SCLC, thereby helping to enhance the immune system's recognition and clearance of these tumor cells.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/24559/1931_D10_1_selected.jpg
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/24559/1931_D10_1_selected.jpg
Figure 2 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56533/1219_G4_3_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56533/1219_G4_3_selected.jpg
Figure 3 RNA cell line category: Cell line enriched (SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000090932-DLL3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000090932-DLL3
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human DLL3
- Species Reactivity
- Human
- Applications
- ADCC, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Delta Like Canonical Notch Ligand 3; Drosophila Delta Homolog 3; Delta3; Delta (Drosophila)-Like 3; Delta-Like 3 (Drosophila); Delta-Like Protein 3; Delta-Like 3; SCDO1
- Gene ID
- 10683
- UniProt ID
- Q9NYJ7
- Long Name
- Delta Like Canonical Notch Ligand 3
- Cellular Localization
- Membrane
- Post Translation Modifications
- Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_058637.1; NP_982353.1
- Function
- Inhibits primary neurogenesis.
May be required to divert neurons along a specific differentiation pathway.
Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "DLL3"
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Mouse Antibody Products
Fab Antibody Products
IgG Antibody Products
ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-212MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-212MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| TAB-213MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-213MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| TAB-214MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-214MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| TAB-215MZ | Mouse Anti-DLL3 Recombinant Antibody (TAB-215MZ) | Cyt, ELISA, FC, Inhib | Mouse IgG2a |
| TAB-212MZ-S(P) | Mouse Anti-DLL3 Recombinant Antibody; scFv Fragment (TAB-212MZ-S(P)) | FC, ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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