Recombinant Mouse Anti-EV71 VP1 Antibody (MA28-7) (CAT#: PABL-090)

Recombinant Mouse Antibody (MA28-7) is capable of binding to EV71 VP1, expressed in Chinese Hamster Ovary cells (CHO).


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  • Published Data
  • Datasheet
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  • COA

Figure 2 NF449 inhibits immunoprecipitation of EV-A71-1095 by MA28-7 but not by 10F0.

Figure 2 NF449 inhibits immunoprecipitation of EV-A71-1095 by MA28-7 but not by 10F0.

EV-A71-1095 concentrated from supernatants of infected cells was incubated with MA28-7 or 10F0 fixed to Protein G beads, in the presence of NF449 at the indicated concentrations, or 200 μM Pirodavir; beads were washed, and immunoprecipitated proteins were examined on Coomassie-stained gels. Molecular weight markers are shown at the left. Arrows at the right indicate capsid proteins VP0 and VP1, and brackets indicate antibody heavy (HC) and light chains (LC).

Nishimura, Y., McLaughlin, N. P., Pan, J., Goldstein, S., Hafenstein, S., Shimizu, H.,... & Bergelson, J. M. (2015). The suramin derivative NF449 interacts with the 5-fold vertex of the enterovirus A71 capsid to prevent virus attachment to PSGL-1 and heparan sulfate. PLoS pathogens, 11(10), e1005184.

Figure 3 NF449 and NF110 inhibit attachment of MA28-7 to mature virions. Purified 35S-labeled mature virions were incubated with MA28-7-coated beads, in the presence of inhibitors as indicated.

Figure 3 NF449 and NF110 inhibit attachment of MA28-7 to mature virions. Purified 35S-labeled mature virions were incubated with MA28-7-coated beads, in the presence of inhibitors as indicated.

Nishimura, Y., McLaughlin, N. P., Pan, J., Goldstein, S., Hafenstein, S., Shimizu, H.,... & Bergelson, J. M. (2015). The suramin derivative NF449 interacts with the 5-fold vertex of the enterovirus A71 capsid to prevent virus attachment to PSGL-1 and heparan sulfate. PLoS pathogens, 11(10), e1005184.


Specifications

  • Immunogen
  • Enterovirus 71 Capsid protein VP1
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • IgG
  • Specificity
  • Tested positive against native EV71 VP1
  • Species Reactivity
  • EV71
  • Clone
  • MA28-7
  • Applications
  • Inhib, WB, ELISA, Neut, FuncS

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • The antibody was validated for Inhib. For details, refer to published data.

Target

  • Alternative Names
  • Capsid protein VP1; VP1

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Single-domain Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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