What condition is the target GDF15 associated with?

Over-expression of human GDF15 (Growth Differentiation Factor 15) is associated with body weight loss, including cachexia. Our monoclonal antibodies that bind and inhibit GDF15 activity are used in research to investigate treatments for these conditions.

What is the purity level of this ADCC enhanced antibody?

This Afuco™ Anti-Human GDF15 ADCC Recombinant Antibody has a purity of greater than 95%, as judged by SDS-polyacrylamide gel electrophoresis. It is an ADCC enhanced antibody produced by our specialized fucosyltransferase-engineered cell line platform.

Afuco™ Anti-Human GDF15 ADCC Recombinant Antibody, ADCC Enhanced

CAT#: AFC-293CL

Anti-GDF15 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. The monoclonal antibodies that bind and inhibit the activity of human GDF15 can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line Hep G2 shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11191/1404_F3_1_selected.jpg

Normal Tissue Figure 2 Placenta

Cytotrophoblasts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11191/27866_A_1_7.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (BEWO, Hep G2, HHSteC, TIME)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130513-GDF15

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Specifications

Host Species
Humanized

Derivation
Humanized

Type
ADCC enhanced antibody

Species Reactivity
Human

Related Disease
Cachexia

Product Property

Purity
>95% as judged by SDS-polyacrylamide gel electrophoresis

Storage
Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.

Target

Alternative Names
GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1

Gene ID
9518

UniProt ID
Q99988

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Potent Gdf15 Inhibitor

We used this ADCC enhanced antibody to inhibit the activity of human GDF15 in our research models. It was effective in our studies related to body weight loss and cachexia associated with GDF15 overexpression. The antibody is produced via the Afuco™ platform, ensuring high quality and specific binding.

High Purity Adcc Antibody

The purity of this humanized antibody was excellent, judged to be greater than 95% by SDS-polyacrylamide gel electrophoresis. We appreciate the enhanced ADCC properties derived from the fucosyltransferase-engineered cell line. It has been a reliable reagent for our experiments targeting Growth Differentiation Factor 15.

Q&As

What condition is the target GDF15 associated with?

A: Over-expression of human GDF15 (Growth Differentiation Factor 15) is associated with body weight loss, including cachexia. Our monoclonal antibodies that bind and inhibit GDF15 activity are used in research to investigate treatments for these conditions.
What is the purity level of this ADCC enhanced antibody?

A: This Afuco™ Anti-Human GDF15 ADCC Recombinant Antibody has a purity of greater than 95%, as judged by SDS-polyacrylamide gel electrophoresis. It is an ADCC enhanced antibody produced by our specialized fucosyltransferase-engineered cell line platform.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-293CL.pdf

MSDS

MSDS - AFC-293CL.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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