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    GDF15

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia.
    Protein class

    Cancer-related genes, Disease related genes, Plasma proteins

    Predicted location

    Intracellular, Secreted (different isoforms)

    Single cell type specificity

    Cell type enhanced (Syncytiotrophoblasts, Urothelial cells, Club cells)

    Immune cell specificity

    Immune cell enhanced (neutrophil)

    Cell line specificity

    Cell line enhanced (BEWO, Hep G2, HHSteC, TIME)

    Interaction

    Homodimer; disulfide-linked (PubMed:29046435). Interacts with GFRAL; ligand of GFRAL which mediates GDF15 internalization and cellular signaling through interaction with RET (PubMed:28953886, 28846097, 28846098, 28846099).

    Molecular function

    Cytokine, Growth factor

    More Types Infomation
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