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  • Recombinant Anti-human GLI3 Intrabody [+36 GFP]

Recombinant Anti-human GLI3 Intrabody [+36 GFP] (CAT#: IAB-B069(G))

Recombinant anti-GLI3 intrabody in fusion with +36GFP works within cells and is directed against specific to the repressor domain of human GLI3, expressed in E. coli cells. Such a scFv constitutes a useful tool for studying transcriptional regulation of the hedgehog pathway in mammals and offers a starting point for developing novel Gli-related therapeutic intrabodies.


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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5534/61_A4_2_selected.jpg
Figure 3 IF staining of human cell line HeLa
Figure 3 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5534/1975_H4_2_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5534/59_A4_1_red_green.jpg
Normal Tissue
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong nuclear positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5534/16128_A_6_6_selected.jpg
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5534/16128_B_7_5.jpg
Figure 6 Testis
Figure 6 Testis
(Preleptotene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5534/16128_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (AF22, WM-115)
Figure 7 RNA cell line category: Cell line enhanced (AF22, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000106571-GLI3

Specifications

  • Immunogen
  • human GLI family zinc finger 3
  • Host Species
  • llama
  • Type
  • vhh-(+36GFP)
  • Cell Penetrating Peptide
  • +36 GFP
    GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
  • Species Reactivity
  • human
  • Applications
  • Antibody assay: Immunocytochemistry; Neutralization; Functional studies

Product Property

  • Purity
  • >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Target

  • Alternative Names
  • GLI3; GLI family zinc finger 3; PHS; ACLS; GCPS; PAPA; PAPB; PAP-A; PAPA1; PPDIV; GLI3FL; GLI3-190; transcriptional activator GLI3; oncogene GLI3; zinc finger protein GLI3; GLI-Kruppel family member GLI3; glioma-associated oncogene family zinc finger 3

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "GLI3"

Recombinant Antibody

CAT Product Name Application Type
MOB-396 Recombinant Anti-human GLI3 Antibody WB, IP, FuncS IgG
MHH-396 Recombinant Human Anti-human GLI3 Antibody ELISA, WB, Neut, FuncS IgG
MOB-0773CT Recombinant Mouse anti-Human GLI3 Monoclonal antibody (EML508) WB
MRO-0659-CN Rabbit Anti-GLI3 Recombinant Antibody (clone JG83-39) WB, IF Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
MOB-396-F(E) Recombinant Anti-human GLI3 Antibody Fab Fragment FC, IP, FuncS Fab
MHH-396-F(E) Recombinant Human Anti-human GLI3 Antibody Fab Fragment IF, Neut, FuncS Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-396-S(P) Recombinant Anti-human GLI3 Antibody scFv Fragment ELISA, WB, FuncS scFv
MHH-396-S(P) Recombinant Human Anti-human GLI3 Antibody scFv Fragment FC, RIA, Biosensors, FuncS scFv

Intrabody

CAT Product Name Application Type
IAB-B069(A) Recombinant Anti-human GLI3 Intrabody [(D-Arg)9] IF, FC, WB, FuncS vhh-(D-Arg)9
IAB-B069(T) Recombinant Anti-human GLI3 Intrabody [Tat] ELISA, WB, ICC, FuncS vhh-Tat

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1452 Hi-Affi™ Rabbit Anti-GLI3 Recombinant Antibody (clone DS1452AB) ICC, IF, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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