Recombinant monoclonal antibody to GM-CSF (Granulocyte-macrophage colony stimulating growth factor). This antibody intended for the prophylaxis and treatment of Rheumatoid arthirtis.
Figure 1 Neutralization by mAbs against GM-CSF of bioactivity of GM-CSF.
Washed TF-1 cells were incubated with titrations of the indicated mAbs and 200 pg/mL rhGM-CSF. After 4 d, metabolic activity of TF-1 cells was measured by the water-soluble tetrazolium assay.
Wang, Y., Thomson, C. A., Allan, L. L., Jackson, L. M., Olson, M., Hercus, T. R., ... & Waddell, T. K. (2013). Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences, 110(19), 7832-7837.
Figure 2 Affinities of the human anti–GM-CSF mAbs.
Shown are examples of SPR data and fit for a representative very-high-affinity (C3) mAb.
Wang, Y., Thomson, C. A., Allan, L. L., Jackson, L. M., Olson, M., Hercus, T. R., ... & Waddell, T. K. (2013). Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences, 110(19), 7832-7837.
Figure 3 Neutralization of bioactivity of GM-CSF by monoclonal autoantibodies (mAbs) against GM-CSF.
Washed TF-1 cells were incubated with titrations of the indicated mAbs and a dose of glycosylated GM-CSF that gave half maximal proliferation, which was produced from human HEK 293 cells.
Wang, Y., Thomson, C. A., Allan, L. L., Jackson, L. M., Olson, M., Hercus, T. R., ... & Waddell, T. K. (2013). Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences, 110(19), 7832-7837.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-183CT | Mouse Anti-CSF2 Recombinant Antibody (TAB-183CT) | ELISA, FC, WB, Block | Mouse IgG |
TAB-185CT | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (4K21) | ELISA, Neut | |
TAB-183CT-S(P) | Mouse Anti-CSF2 Recombinant Antibody; scFv Fragment (TAB-183CT-S(P)) | ELISA, FC, WB, Block | Mouse scFv |
TAB-185CT-S(P) | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody scFv Fragment (4K21) | ELISA, Neut | |
TAB-183CT-F(E) | Mouse Anti-CSF2 Recombinant Antibody; Fab Fragment (TAB-183CT-F(E)) | ELISA, FC, WB, Block | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-184CT | Human Anti-CSF2 Recombinant Antibody (TAB-184CT) | ELISA, FC, WB, Block | Chimeric (Mouse/Human) IgG1, κ |
TAB-184CT-S(P) | Human Anti-CSF2 Recombinant Antibody; scFv Fragment (TAB-184CT-S(P)) | ELISA, FC, WB, Block | Human scFv |
TAB-184CT-F(E) | Human Anti-CSF2 Recombinant Antibody; Fab Fragment (TAB-184CT-F(E)) | ELISA, FC, WB, Block | Chimeric (Mouse/Human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-186CT | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (hGM4/1-34) | ELISA, Neut | Humanized antibody |
TAB-186CT-S(P) | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody scFv Fragment (hGM4/1-34) | ELISA, Neut | Humanized antibody |
TAB-186CT-F(E) | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody Fab Fragment (hGM4/1-34) | ELISA, Neut | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-177CT-F(E) | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody Fab Fragment (KB002) | ELISA, Neut | Human antibody |
TAB-178CT-F(E) | Human Anti-CSF2 Recombinant Antibody; Fab Fragment (TAB-178CT-F(E)) | ELISA, Neut, FC, WB | Human Fab |
TAB-179CT-F(E) | Human Anti-CSF2 Recombinant Antibody; Fab Fragment (TAB-179CT-F(E)) | ELISA, WB, Neut | Human Fab |
TAB-180CT-F(E) | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody Fab Fragment (F1) | ELISA, FC, Neut | Human antibody |
TAB-187CT-F(E) | Human Anti-CSF2 Recombinant Antibody; Fab Fragment (TAB-187CT-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-511CQ | Recombinant Mouse Anti-CSF2 Antibody (CBL568) | Neut | IgG1 |
NEUT-513CQ | Rat Anti-CSF2 Recombinant Antibody (clone 23B6) | Neut | Rat IgG2a |
NEUT-515CQ | Mouse Anti-CSF2 Recombinant Antibody (clone 7U1) | IHC, Neut, WB | Mouse IgG1 |
NEUT-516CQ | Mouse Anti-CSF2 Recombinant Antibody (clone BVD2-21C11) | Neut, FC, ICC, IF, WB, IP, IHC-Fr | Mouse IgG2a, κ |
NEUT-517CQ | Rat Anti-CSF2 Recombinant Antibody (clone BVD2-23B6) | ELISA, FC, IP, Neut | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-512CQ | Rat Anti-CSF2 Recombinant Antibody (clone 22E9), Biotin | Block, ELISA, WB | Rat IgG2a |
NEUT-514CQ | Rat Anti-CSF2 Recombinant Antibody (clone 31G6) | Block, ELISA, WB | Rat IgG1 |
NEUT-525CQ | Rat Anti-Csf2 Recombinant Antibody (clone CBL251) | Inhib | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4580 | Hi-Affi™ Rabbit Anti-CSF2 Recombinant Antibody (clone TH92DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0431-CN-S(P) | Human Anti-CSF2 Recombinant Antibody; scFv Fragment (HPAB-0431-CN-S(P)) | ELISA, FC, Neut | Human scFv |
HPAB-0014-FY-S(P) | Human Anti-CSF2 Recombinant Antibody (clone hGM4/35); scFv Fragment | ELISA | Human scFv |
PSBC-337 | Human Anti-CSF2 Recombinant Antibody (clone F1); scFv Fragment | ELISA, FC, Neut | Human scFv |
PSBC-338 | Mouse Anti-CSF2 Recombinant Antibody (clone 4D4); scFv Fragment | ELISA, FC, Neut | Mouse scFv |
PABJ-0112-S(P) | Human Anti-CSF2 Recombinant Antibody (clone EV1007); scFv Fragment | ELISA, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0014-FY | Human Anti-CSF2 Recombinant Antibody (clone hGM4/35) | ELISA | Human IgG |
PABC-337 | Human Anti-CSF2 Recombinant Antibody (clone F1) | ELISA, FC, Neut | Human IgG |
PABC-338 | Mouse Anti-CSF2 Recombinant Antibody (clone 4D4) | ELISA, FC, Neut | Mouse IgG |
FN-105CQ | Rat Anti-Csf2 Recombinant Antibody (clone MP1-22E9) | ELISA, Neut, WB | Rat IgG2a |
HPAB-N0052-YC | Human Anti-CSF2 Recombinant Antibody (HPAB-N0052-YC) | ELISA, Block | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-259 | Afuco™ Anti-CSF2 ADCC Recombinant Antibody (Namilumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
AFC-TAB-H44 | Afuco™ Anti-CSF2 ADCC Recombinant Antibody (Lenzilumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1090-FY-S(P) | Human Anti-CSF2 Recombinant Antibody; scFv Fragment (HPAB-1090-FY-S(P)) | ELISA | Human scFv |
HPAB-1091-FY-S(P) | Human Anti-CSF2 Recombinant Antibody; scFv Fragment (HPAB-1091-FY-S(P)) | ELISA | Human scFv |
HPAB-1092-FY-S(P) | Human Anti-CSF2 Recombinant Antibody; scFv Fragment (HPAB-1092-FY-S(P)) | ELISA | Human scFv |
HPAB-1093-FY-S(P) | Human Anti-CSF2 Recombinant Antibody; scFv Fragment (HPAB-1093-FY-S(P)) | ELISA | Human scFv |
HPAB-1094-FY-S(P) | Mouse Anti-CSF2 Recombinant Antibody; scFv Fragment (HPAB-1094-FY-S(P)) | ELISA | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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