Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (C5) (CAT#: TAB-182CT)

Recombinant monoclonal antibody to GM-CSF (Granulocyte-macrophage colony stimulating growth factor). This antibody intended for the prophylaxis and treatment of Rheumatoid arthirtis.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Neut

Figure 1 Neutralization by mAbs against GM-CSF of bioactivity of GM-CSF.

Figure 1 Neutralization by mAbs against GM-CSF of bioactivity of GM-CSF.

Washed TF-1 cells were incubated with titrations of the indicated mAbs and 200 pg/mL rhGM-CSF. After 4 d, metabolic activity of TF-1 cells was measured by the water-soluble tetrazolium assay.

Wang, Y., Thomson, C. A., Allan, L. L., Jackson, L. M., Olson, M., Hercus, T. R., ... & Waddell, T. K. (2013). Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences, 110(19), 7832-7837.

Inhib

Figure 2 Neutralization of bioactivity of GM-CSF by monoclonal autoantibodies (mAbs) against GM-CSF.

Figure 2 Neutralization of bioactivity of GM-CSF by monoclonal autoantibodies (mAbs) against GM-CSF.

Washed TF-1 cells were incubated with titrations of the indicated mAbs and a dose of glycosylated GM-CSF that gave half maximal proliferation, which was produced from human HEK 293 cells.

Wang, Y., Thomson, C. A., Allan, L. L., Jackson, L. M., Olson, M., Hercus, T. R., ... & Waddell, T. K. (2013). Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences, 110(19), 7832-7837.

SPR

Figure 3 Affinities of the human anti–GM-CSF mAbs.

Figure 3 Affinities of the human anti–GM-CSF mAbs.

Shown are examples of SPR data and fit for a representative high-affinity (C5) mAb.

Wang, Y., Thomson, C. A., Allan, L. L., Jackson, L. M., Olson, M., Hercus, T. R., ... & Waddell, T. K. (2013). Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences, 110(19), 7832-7837.


Specifications

  • Host Species
  • Human
  • Type
  • Human antibody
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • C5
  • Applications
  • Neut, SPR, Inhib, ELISA, FC
  • Related Disease
  • Rheumatoid arthirtis

Applications

  • Application Notes
  • The GM-CSF (GranuloCytotoxicitye-macrophage colony stimulating growth factor) antibody has been reported in applications of Neutralization, Surface Plasmon Resonance, Inhibition, Enzyme-linked Immunosorbent Assay, Flow Cytometry.

Target

  • Alternative Names
  • GMCSF

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone C5"

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Chimeric Antibody

CAT Product Name Application Type
TAB-184CT Human Anti-CSF2 Recombinant Antibody (TAB-184CT) ELISA, FC, WB, Block Chimeric (Mouse/Human) IgG1, κ
TAB-184CT-S(P) Human Anti-CSF2 Recombinant Antibody; scFv Fragment (TAB-184CT-S(P)) ELISA, FC, WB, Block Human scFv
TAB-184CT-F(E) Human Anti-CSF2 Recombinant Antibody; Fab Fragment (TAB-184CT-F(E)) ELISA, FC, WB, Block Chimeric (Mouse/Human) Fab

Blocking Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4580 Hi-Affi™ Rabbit Anti-CSF2 Recombinant Antibody (clone TH92DS) WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-259 Afuco™ Anti-CSF2 ADCC Recombinant Antibody (Namilumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
AFC-TAB-H44 Afuco™ Anti-CSF2 ADCC Recombinant Antibody (Lenzilumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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