Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (C5) (CAT#: TAB-182CT)
Recombinant monoclonal antibody to GM-CSF (Granulocyte-macrophage colony stimulating growth factor). This antibody intended for the prophylaxis and treatment of Rheumatoid arthirtis.
Specific Inquiry
Neut
Figure 1 Neutralization by mAbs against GM-CSF of bioactivity of GM-CSF.
Washed TF-1 cells were incubated with titrations of the indicated mAbs and 200 pg/mL rhGM-CSF. After 4 d, metabolic activity of TF-1 cells was measured by the water-soluble tetrazolium assay.
Wang, Y., Thomson, C. A., Allan, L. L., Jackson, L. M., Olson, M., Hercus, T. R., ... & Waddell, T. K. (2013). Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences, 110(19), 7832-7837.
Inhib
Figure 2 Neutralization of bioactivity of GM-CSF by monoclonal autoantibodies (mAbs) against GM-CSF.
Washed TF-1 cells were incubated with titrations of the indicated mAbs and a dose of glycosylated GM-CSF that gave half maximal proliferation, which was produced from human HEK 293 cells.
Wang, Y., Thomson, C. A., Allan, L. L., Jackson, L. M., Olson, M., Hercus, T. R., ... & Waddell, T. K. (2013). Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences, 110(19), 7832-7837.
SPR
Figure 3 Affinities of the human anti–GM-CSF mAbs.
Shown are examples of SPR data and fit for a representative high-affinity (C5) mAb.
Wang, Y., Thomson, C. A., Allan, L. L., Jackson, L. M., Olson, M., Hercus, T. R., ... & Waddell, T. K. (2013). Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences, 110(19), 7832-7837.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- C5
- Applications
- Neut, SPR, Inhib, ELISA, FC
- Related Disease
- Rheumatoid arthirtis
Applications
- Application Notes
- The GM-CSF (GranuloCytotoxicitye-macrophage colony stimulating growth factor) antibody has been reported in applications of Neutralization, Surface Plasmon Resonance, Inhibition, Enzyme-linked Immunosorbent Assay, Flow Cytometry.
Target
- Alternative Names
- GMCSF
- Gene ID
- 1437
Related Resources
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-481 | Human Anti-CSF2 Recombinant Antibody (PABL-481) | Neut | Human IgG |
| MOB-1737MZ | Recombinant Mouse Anti-Human CSF2 Antibody (clone 230) | ELISA | Mouse antibody |
| HPAB-0014-FY | Human Anti-CSF2 Recombinant Antibody (HPAB-0014-FY) | ELISA | Human IgG |
| HPAB-0136-FY | Human Anti-CSF2 Recombinant Antibody (clone MSB-0010628) | Inhib | Humanized IgG1, κ |
| FN-240CQ | Mouse Anti-Csf2 Recombinant Antibody (clone CBL-1345) | Block, FuncS | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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