Mouse Anti-HAVCR2 Recombinant Antibody (clone F38-2E2) (CAT#: HPAB-0192-LSX)
Recombinant monoclonal antibody to HAVCR2. Clone F38-2E2 is a mouse IgG1, κ that can be potentially used in the treatment of cancer.
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FuncS
Figure 1 Mixed lymphocyte reaction on day 1 or day 7 following treatment with F38-2E2, mAb15 or an isotype control.
Supernatants were assessed for their expression of IL-1β, TNFα and IFN-γ at the time points indicated.
FuncS
Figure 2 Expression of GM-CSF (FIG. A) and IL-6 (FIG. B) from activated macrophages from two different donors one day following treatment with anti-TIM-3 antibodies. Controls included F38-2E2, a commercially available anti-TIM-3 antibody and mIgG isotype controls.
FuncS
Figure 3 PBMC from a donor with low LILRB2 showed diminished modulation of GM-CSF, IL-1β, and TNFα expression with mAb15 compared to F38-2E2.
Donor KP42331 expressed LILRB2 (left panel, top). Donor KP42334 showed low expression of LILRB2 (left panel, bottom). Antibodies were the commercially available anti-TIM-3 antibody F38-2E2 and anti-TIM-3 antibody mAb15. mIgG1 served as an isotype control.
FuncS
Figure 4 Dose curve of release of IL-1β from macrophages stimulated by LPS following treatment with different doses of antibodies.
Antibodies were the commercially available anti-TIM-3 antibody F38-2E2 (circles), anti-TIM-3 antibody mAb15 (squares) and anti-LILRB2 (clone 287219) (inverted triangles). mIgG1 isotype (diamonds) and no antibody (triangles) served as a negative control. Data were collected at 24 hr, 48 hr, and 3 days post-treatment as indicated.
FuncS
Figure 5 A graph demonstrating a dose curve of release of IL-1β from macrophages stimulated by LPS following treatment with different doses of antibodies.
Antibodies were the commercially available anti-TIM-3 antibody F38-2E2 (circles), anti-TIM-3 antibody mAb15 (diamonds), and commercially available anti-LILRB2 antibody (clone 287219) (triangles). Data were collected at day 1-post-treatment. Data were normalized.
FuncS
Figure 6 A graph demonstrating a dose curve of release of TNFα from macrophages stimulated by LPS following treatment with different doses of antibodies.
Antibodies were the commercially available anti-TIM-3 antibody F38-2E2 (circles), anti-TIM-3 antibody mAb15 (diamonds), and commercially available anti-LILRB2 antibody (triangles). Data were collected at day 3 post-treatment. Data were normalized.
FuncS
Figure 7 A graph demonstrating a dose curve of release of TNFα from macrophages stimulated by HMGB-1 following treatment with different doses of antibodies.
Antibodies were the commercially available anti-TIM-3 antibody F38-2E2 (circles) and anti-TIM-3 antibody mAb15 (squares). Data were normalized.
FuncS
Figure 8 Graphs demonstrating release of IL-1β (FIGS. A), TNFα (FIGS. B) and IL-6 (FIGS. C) from macrophages stimulated by HMGB-1.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human HAVCR2
- Species Reactivity
- Human
- Clone
- F38-2E2
- Applications
- ELISA, WB, FC, FuncS
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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|---|---|---|---|
| NEUT-893CQ | Rat Anti-Havcr2 Recombinant Antibody (clone B8.2C12) | Block, FC | Rat IgG1 |
| NEUT-894CQ | Rat Anti-Havcr2 Recombinant Antibody (clone RMT3-23) | Block, FC | Rat IgG2a |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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