DRB1*04:01/Human HER2 (KVPIKWMALESILRRRF) MHC Tetramer (CAT#: MHC-YF862)

This product is a MHC tetramer of biotinylated peptide/MHC complex composed HER2-derived peptide of KVPIKWMALESILRRRF sequence covering 883-899 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.


Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Allele
  • DRB1*04:01
  • Class
  • Class II
  • MHC Species
  • Human
  • Antigen
  • HER2
  • Antigen Species
  • Human
  • Peptide
  • KVPIKWMALESILRRRF
  • Range
  • 883-899
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
  • Alternative Names
  • NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

Related Resources

  • Related Diseases

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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