Anti-Human HIF-1alpha Recombinant Antibody (6A9) (CAT#: TAB-080CT)
Recombinant monoclonal antibody 6A9 to hydroxylated hypoxia inducible factor 1-α (HIF-1α). The isotype is mouse IgG2a. The antibody has been tested in western blot (1/200) with cell Lysates and Immunofluorescence (1/100) assays. This antibody intended for the prophylaxis and treatment studies of Pancreatic cancer, Colorectal cancer.
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WB
Figure 1 Validation of monoclonal antibodies against hydroxylated proline 402 or 564 containing peptides of the HIF-1α ODD region.
Clone 6A9 was specific for hydroxylated proline 564.
Rolfo, A., Many, A., Racano, A., Tal, R., Tagliaferro, A., Ietta, F., ... & Caniggia, I. (2010). Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies. PloS one, 5(10), e13288.
IB
Figure 2 HIF-1α hydroxylation during normal placentation and in preeclampsia.
Representative immunoblots showing reduced HIF-1a hydroxylation at P564 (6A9) in preeclamptic placentae (E-PE, n = 12) relative to preterm controls (PTC n = 12).
Rolfo, A., Many, A., Racano, A., Tal, R., Tagliaferro, A., Ietta, F., ... & Caniggia, I. (2010). Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies. PloS one, 5(10), e13288.
FuncS
Figure 1 Analysis of mAb reactivity with hCD200R by orientation via antibody immobilization.
Shows the mean fluorescence intensity ± SEM for each spot of all replicates. Serial two-fold dilutions of capture human CD200R mAb OX108, DX136 and DX147 and control rat CD4 mAb OX68 were arrayed onto epoxy-coated microscope slides. Each mAb dilution series was arrayed in quadruplicate of 2 rows of 6 spots, ranging in concentration from 80 μg ml-1 (first spot) to 0.16 μg/ml (spot 10), with control spotting buffer containing 0.5 mg/ml BSA in the last two spots.
LETARTE, Michelle, et al. Analysis of leukocyte membrane protein interactions using protein microarrays. BMC biochemistry, 2005, 6.1: 2.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- 6A9
- Applications
- FuncS
- Related Disease
- Pancreatic cancer, Colorectal cancer
Applications
- Application Notes
- This antibody has been reported for use in Function Assay.
Target
- Alternative Names
- HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha
- Gene ID
- 3091
- UniProt ID
- Q16665
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
Mouse Antibody Products
Rabbit Monoclonal Antibody Products
Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1828z | Mouse Anti-HIF1A Recombinant Antibody (clone 6F11) | WB, ELISA, IF | Mouse IgG1 |
| VS3-XY804 | Mouse Anti-HIF1A Recombinant Antibody (clone 5B1) | IHC | |
| VS3-XY805 | Mouse Anti-HIF1A Recombinant Antibody (clone 1A3) | ELISA, WB, IHC, ICC | Mouse IgG1 |
| VS3-WK1354 | Mouse Anti-HIF1A Recombinant Antibody (VS3-WK1354) | WB, IHC | Mouse IgG |
| VS7-0425-WR34 | Mouse Anti-HIF1A Monoclonal Antibody (VS7-0425-WR34) | WB, IHC-P, IF, ICC, ELISA | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
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