Human Anti-HIV-1 Env Recombinant Antibody (clone 17B) (CAT#: PABL-514)
Recombinant Human Antibody (17B) is capable of binding to HIV-1 Env, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 Env mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 Env proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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Figure 1 Flow cytometry analysis of 17b antibody binding to the HIV-1 envelope glycoproteins.
Cells (293T) expressing the cytoplasmic tail-deleted YU2 HIV-1 envelope glycoproteins were incubated with the indicated molecules and then analyzed for 17b antibody binding (PE) by two-color flow cytometry.
Si, Z., Madani, N., Cox, J. M., Chruma, J. J., Klein, J. C., Schön, A., ... & Chaiken, I. (2004). Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins. Proceedings of the National Academy of Sciences, 101(14), 5036-5041.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Tested positive against HIV-1 Env
- Species Reactivity
- HIV-1
- Clone
- 17B
- Applications
- FC Assay-dependent
Neut Assay-dependent
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Assay-dependent
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-057 | Recombinant Anti-HIV-1 env VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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