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Arcitumomab (TAB-014-F(E))

Recombinant monoclonal antibody Fragment Fab to Human CEA. Technetium (99mTc) arcitumomab is a drug used for the diagnostic imaging of colorectal cancers. It consists of the Fab' fragment of a monoclonal antibody (arcitumomab, trade name CEA-Scan) and a radionuclide, technetium-99m. Technetium (99mTc) arcitumomab is an immunoconjugate. Arcitumomab is a Fab' fragment of IMMU-4, a murine IgG1 monoclonal antibody extracted from the ascites of mice. The enzyme pepsin cleaves the F(ab')2 fragment off the antibody. From this, the Fab' fragment is prepared by mild reduction. Before application, arcitumomab is reconstituted with a solution of the radioactive agent sodium pertechnetate (99mTc) from a technetium generator.      
  • Datasheet

Specifications
Immunogen
Full length native protein (CEA)
Host
Mouse
Derivation
Mouse
Type
Fab' - G1
Specificity
Tested positive against native human antigen
Species Reactivity
Human
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
Trade name
Technetium (99mTc) arcitumomab
CAS NO.
154361-48-5
Generic Name
Arcitumomab
Biological Half-Life
13 ± 4 hours
ATC Code
V09IA06
UNII
029JF1SCU8
M.W.
50 kDa
Related Disease
Colorectal cancers (radiodiagnostic imaging of tumors)
Target
Alternative Names
Arcitumomab; Technetium (99mTc) arcitumomab; 154361-48-5; IMMU-4; NP-4; CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); BGP
Entrez Gene ID
634
UniProt ID
P13688

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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