Anti-Human CEA Recombinant Antibody Fab Fragment (Arcitumomab)

Name: Anti-Human CEA Recombinant Antibody Fab Fragment (Arcitumomab)
SKU: TAB-014-F(E)
Rating: 5 (1 reviews)

CAT#: TAB-014-F(E)

Recombinant monoclonal antibody Fragment Fab to Human CEA. Technetium (99mTc) arcitumomab is a drug used for the diagnostic imaging of colorectal cancers. It consists of the Fab' fragment of a monoclonal antibody (arcitumomab, trade name CEA-Scan) and a radionuclide, technetium-99m. Technetium (99mTc) arcitumomab is an immunoconjugate. Arcitumomab is a Fab' fragment of IMMU-4, a murine IgG1 monoclonal antibody extracted from the ascites of mice. The enzyme pepsin cleaves the F(ab')₂ fragment off the antibody. From this, the Fab' fragment is prepared by mild reduction. Before application, arcitumomab is reconstituted with a solution of the radioactive agent sodium pertechnetate (99mTc) from a technetium generator.

Gene Expression

Normal Tissue Figure 1 Colon

Enterocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2146/5911_A_8_3.jpg

Normal Tissue Figure 2 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2146/5911_A_9_5.jpg

RNA Expression Figure 3 RNA cell line category: Group enriched (CAPAN-2, Hep G2, OE19, RT4, SK-MEL-30)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000079385-CEACAM1

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Specifications

Immunogen
Full length native protein (CEA)

Host Species
Mouse

Derivation
Mouse

Type
Fab' - G1

Specificity
Tested positive against native human antigen

Species Reactivity
Human

Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.

Trade name
Technetium (99mTc) arcitumomab

CAS
154361-48-5

Generic Name
Arcitumomab

Biological Half-Life
13 ± 4 hours

ATC Code
V09IA06

UNII
029JF1SCU8

MW
50 kDa

Related Disease
Colorectal cancers (radiodiagnostic imaging of tumors)

Product Property

Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.

Target

Alternative Names
Arcitumomab;Technetium (99mTc) arcitumomab;154361-48-5;IMMU-4;NP-4;CEACAM1;carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein);BGP;carcinoembryonic antigen-related cell adhesion molecule 1;BGP1;CD66a;antigen CD66;CD66a antigen

Gene ID
634

UniProt ID
P13688

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Biosimilar Overview

Please refer to Arcitumomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Arcitumomab.

Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-014-F(E).pdf

MSDS

MSDS - TAB-014-F(E).pdf

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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