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    Anti-Human CEA Recombinant Antibody Fab Fragment (Arcitumomab)

    CAT#: TAB-014-F(E)

    Recombinant monoclonal antibody Fragment Fab to Human CEA. Technetium (99mTc) arcitumomab is a drug used for the diagnostic imaging of colorectal cancers. It consists of the Fab' fragment of a monoclonal antibody (arcitumomab, trade name CEA-Scan) and a radionuclide, technetium-99m. Technetium (99mTc) arcitumomab is an immunoconjugate. Arcitumomab is a Fab' fragment of IMMU-4, a murine IgG1 monoclonal antibody extracted from the ascites of mice. The enzyme pepsin cleaves the F(ab')2 fragment off the antibody. From this, the Fab' fragment is prepared by mild reduction. Before application, arcitumomab is reconstituted with a solution of the radioactive agent sodium pertechnetate (99mTc) from a technetium generator.

    Gene Expression
    ❮
    Figure 1 Colon Figure 2 Kidney Figure 3 RNA cell line category: Group enriched (CAPAN-2, Hep G2, OE19, RT4, SK-MEL-30)
    ❯

    Specifications

    • Immunogen
    • Full length native protein (CEA)
    • Host Species
    • Mouse
    • Derivation
    • Mouse
    • Type
    • Fab' - G1
    • Specificity
    • Tested positive against native human antigen
    • Species Reactivity
    • Human
    • Applications
    • Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
    • Trade name
    • Technetium (99mTc) arcitumomab
    • CAS
    • 154361-48-5
    • Generic Name
    • Arcitumomab
    • Biological Half-Life
    • 13 ± 4 hours
    • ATC Code
    • V09IA06
    • UNII
    • 029JF1SCU8
    • MW
    • 50 kDa
    • Related Disease
    • Colorectal cancers (radiodiagnostic imaging of tumors)

    Product Property

    • Purity
    • >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
    • Storage
    • Store at -20°C. Avoid multiple freeze/thaw cycles.

    Target

    • Alternative Names
    • Arcitumomab;Technetium (99mTc) arcitumomab;154361-48-5;IMMU-4;NP-4;CEACAM1;carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein);BGP;carcinoembryonic antigen-related cell adhesion molecule 1;BGP1;CD66a;antigen CD66;CD66a antigen
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    Biosimilar Overview

    Please refer to Arcitumomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Arcitumomab.

    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - TAB-014-F(E).pdf

    MSDS

    MSDS - TAB-014-F(E).pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

    Protocol & Troubleshooting

    Immunofluorescence (IF)

    We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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