Arcitumomab (TAB-014-F(E))
Recombinant monoclonal antibody Fragment Fab to Human CEA. Technetium (99mTc) arcitumomab is a drug used for the diagnostic imaging of colorectal cancers. It consists of the Fab' fragment of a monoclonal antibody (arcitumomab, trade name CEA-Scan) and a radionuclide, technetium-99m. Technetium (99mTc) arcitumomab is an immunoconjugate. Arcitumomab is a Fab' fragment of IMMU-4, a murine IgG1 monoclonal antibody extracted from the ascites of mice. The enzyme pepsin cleaves the F(ab')2 fragment off the antibody. From this, the Fab' fragment is prepared by mild reduction. Before application, arcitumomab is reconstituted with a solution of the radioactive agent sodium pertechnetate (99mTc) from a technetium generator.
Specifications
- Immunogen
- Full length native protein (CEA)
- Host
- Mouse
- Derivation
- Mouse
- Type
- Fab' - G1
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
- Trade name
- Technetium (99mTc) arcitumomab
- CAS NO.
- 154361-48-5
- Generic Name
- Arcitumomab
- Biological Half-Life
- 13 ± 4 hours
- ATC Code
- V09IA06
- UNII
- 029JF1SCU8
- M.W.
- 50 kDa
- Related Disease
- Colorectal cancers (radiodiagnostic imaging of tumors)
Target
- Alternative Names
- Arcitumomab; Technetium (99mTc) arcitumomab; 154361-48-5; IMMU-4; NP-4; CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); BGP
- Entrez Gene ID
- 634
- UniProt ID
- P13688
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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