Recombinant monoclonal antibody specifically binds to IAV HA, expressed in Chinese Hamster Ovary cells(CHO).
Figure 1 CCI showed virus neutralizing activity in TMN after removal of head-binding antibodies.
Correct folding of major epitopes for GH HA1 from A/Hong Kong/1/68 (H3N2) was confirmed by appropriate Ab binding profiles. GH HA1 from A/Hong Kong/1/68 (H3N2) and ectodomain H3 rHA from A/Aichi/1/68 (H3N2) were coated on a nickel-coated plate, an ELISA was performed by using rabbit antisera and a panel of conformation specific mAbs.
Trost, J. F., LeMasters, E. H., Liu, F., Carney, P., Lu, X., Sugawara, K., ... & Katz, J. M. (2018). Development of a high-throughput assay to detect antibody inhibition of low pH induced conformational changes of influenza virus hemagglutinin. PloS one, 13(6), e0199683.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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