Human Anti-IGHE (clone Omalizumab) scFv-Fc Chimera
CAT#: VS-0425-FY120
Anti-IGHE scFv-Fc is a recombinant antibody designed to target Immunoglobulin E (IgE), a key player in allergic reactions. The scFv portion provides specific binding to IgE, while the Fc region enhances stability and may offer additional benefits. This format is being developed to neutralize IgE, aiming to prevent it from triggering allergic responses.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211891-IGHE
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Specifications
- Immunogen
- Human IgE protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IGHE
- Species Reactivity
- Human
- Clone
- Omalizumab
- Applications
- ELISA, Blocking
- Related Disease
- Toxocariasis and Allergic Rhinitis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 0.1 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Immunoglobulin Heavy Constant Epsilon
- Gene ID
- 3497
- UniProt ID
- P01854
- Long Name
- Immunoglobulin Heavy Constant Epsilon
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- Glycosylation at Asn21, Asn49, Asn99, Asn146, Asn252, Asn264, and Asn275
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect IGHE_HUMAN
Glycosylation from GlyGen 8 sites, 96 N-linked glycans (8 sites)
- Function
- Constant region of immunoglobulin heavy chains.
Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.
In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.
Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens.
The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.
Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.
The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IGHE_HUMAN,P01854
[Isoform 1]: Constant region of secreted IgE, also known as the Fc region of IgE antibody.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone Omalizumab"
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-092 | Recombinant Anti-human IGHE VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-755 | Anti-IGHE Recombinant Antibody (TAB-755) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
| TAB-007 | Anti-Human IGHE Recombinant Antibody (Omalizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L061R | anti-IGHE immunotoxin (Fab)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-256CQ-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (TAB-256CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-257CQ-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (TAB-257CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-256CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-256CQ-F(E)) | ELISA, FC, WB | Human Fab |
| TAB-257CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-257CQ-F(E)) | ELISA, FC, WB | Human Fab |
| TAB-258CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-258CQ-F(E)) | ELISA, FC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0168-LSX | Mouse Anti-IGHE Recombinant Antibody (clone MaE10) | ELISA, FC | Mouse IgG1 |
| HPAB-0169-LSX | Mouse Anti-IGHE Recombinant Antibody (clone MAE11) | ELISA, FC, SPR | Mouse IgG2 |
| HPAB-0170-LSX | Human Anti-IGHE Recombinant Antibody (clone 235-5.2) | ELISA, FC | Humanized IgG1 |
| HPAB-0171-LSX | Human Anti-IGHE Recombinant Antibody (HPAB-0171-LSX) | ELISA, RIA | Human IgG |
| HPAB-0172-LSX | Human Anti-IGHE Recombinant Antibody (HPAB-0172-LSX) | ELISA, RIA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0168-LSX-S(P) | Mouse Anti-IGHE Recombinant Antibody (clone MaE10); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0169-LSX-S(P) | Mouse Anti-IGHE Recombinant Antibody (clone MAE11); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0170-LSX-S(P) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0171-LSX-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (HPAB-0171-LSX-S(P)) | ELISA, RIA | Human scFv |
| HPAB-0028-YJ-S(P) | Human Anti-IGHE Recombinant Antibody (clone E26); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0168-LSX-F(E) | Mouse Anti-IGHE Recombinant Antibody (clone MaE10); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0169-LSX-F(E) | Mouse Anti-IGHE Recombinant Antibody (clone MAE11); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0170-LSX-F(E) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0171-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0171-LSX-F(E)) | ELISA, RIA | Human Fab |
| HPAB-0028-YJ-F(E) | Human Anti-IGHE Recombinant Antibody (clone E26); Fab Fragment | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-007 | Afuco™ Anti-IGHE ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-007) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-255 | Afuco™ Anti-IGHE ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-255) | IP, IF, FuncS, FC, Neut | ADCC enhanced antibody |
| AFC-TAB-755 | Afuco™ Anti-IGHE ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-755) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC368 | Recombinant Anti-IGHE Vesicular Antibody, EV Displayed (VS-0425-YC368) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3456 | Anti-Sheep IGHE Immunohistochemistry Kit | IHC | |
| VS-0525-XY3457 | Anti-Horse IGHE Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC218 | Recombinant Anti-IGHE (HLP motif x FcεRI binding site) Biparatopic Antibody, Tandem scFv | ELISA, FC, IF, IP, Neut | Tandem scFv |
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