Human Anti-IGHE (clone Omalizumab) scFv-Fc Chimera (CAT#: VS-0425-FY120)

• Immunogen
• Human IgE protein.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human IGHE

• Species Reactivity
• Human

• Clone
• Omalizumab

• Applications
• ELISA, Blocking

• Related Disease
• Toxocariasis and Allergic Rhinitis

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• ELISA: 0.1 μg/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Immunoglobulin Heavy Constant Epsilon

• Gene ID
• 3497

• UniProt ID
• P01854

• Long Name
• Immunoglobulin Heavy Constant Epsilon

• Cellular Localization
• Cell membrane, Secreted

• Post Translation Modifications
• Glycosylation at Asn21, Asn49, Asn99, Asn146, Asn252, Asn264, and Asn275
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect IGHE_HUMAN
  Glycosylation from GlyGen 8 sites, 96 N-linked glycans (8 sites)

• Function
• Constant region of immunoglobulin heavy chains.
  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.
  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.
  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens.
  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.
  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.
  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IGHE_HUMAN,P01854
  [Isoform 1]: Constant region of secreted IgE, also known as the Fc region of IgE antibody.

• TAB-007-mRNA
• Human Anti-IGHE Antibody (clone Omalizumab), mRNA

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