Recombinant Anti-IGHE (HLP motif x FcεRI binding site) Biparatopic Antibody, Tandem scFv (CAT#: VS-0525-YC218)

The Recombinant Anti-IGHE (HLP motif x FcεRI binding site) Biparatopic Antibody, Tandem scFv is a biparatopic antibody (bpAb) designed for high-affinity, simultaneous binding to two distinct IGHE epitopes. This construct employs tandem scFv arms. One scFv binds to the (424)HLP(426) motif, while the other targets a different epitope strongly overlapping with the FcεRI binding site, which explains its superior capacity to inhibit the IgE:FcεRI interaction on basophils and mast cells.

Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
RNA Expression

Specifications

  • Host Animal 1
  • Mouse
  • Host Animal 2
  • Human
  • Specificity
  • Human IGHE
  • Species Reactivity
  • Human
  • Type
  • Tandem scFv
  • Valency
  • 1 + 1
  • Epitope 1
  • (424)HLP(426) motif
  • Epitope 2
  • An epitope overlaping strongly with the FcεRI binding site.
  • Purity
  • >90%
  • Purification
  • Affinity purified
  • Applications
  • ELISA, FC, IF, IP, Neut
  • Concentration
  • Lot specific
  • Buffer
  • PBS, pH 7.4
  • Preservative
  • No preservatives
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
  • Long Name
  • Immunoglobulin Heavy Constant Epsilon

Target

  • Introduction
  • IgE is a member of the immunoglobulin family that mediates allergic responses such as asthma, food allergies, type 1 hypersensitivity and the familiar sinus inflammation suffered on a widespread basis. IgE is secreted by, and expressed on the surface of, B-cells.
  • Alternative Names
  • IGHE; Immunoglobulin heavy constant epsilon;

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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